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Exarafenib

CAT: 0804-HY-147268-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-147268-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Exarafenib (RAF/KIN_2787) is an orally-available, selective pan-RAF inhibitor. Exarafenib is effective in RAF-dependent cancers, including all classes of BRAF alterations. Exarafenib suppresses MAPK signaling in RAF-dependent melanoma cell lines. Exarafenib has anticancer activity[1][2].
CAS Number
2639957-39-2
Product Name Alternative
RAF/KIN_2787
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
P38 MAPK; Raf
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/exarafenib.html
Purity
99.68
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC1=CC=C(NC(N2C[C@@H](CC2)CC(F)(F)F)=O)C=C1C3=CC(N[C@H](C)CO)=NC(N4CCOCC4)=C3
Molecular Formula
C26H34F3N5O3
Molecular Weight
521.58
Precautions
H302, H315, H319, H335
References & Citations
[1]Miller N, et, al. Antitumor activity of KIN-2787, a next-generation pan-RAF inhibitor, in combination with MEK inhibition in preclinical models of human NRAS mutant melanoma.2022 Jun 2;40 (16) : e15099.|[2]WHO Drug Information. International Nonproprietary Names for Pharmaceutical
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
P38 MAPK; Raf

Alternative Products

CatalogName
BA6513-50Exarafenib

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