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Recombinant Human Tissue Factor Pathway Inhibitor

CAT: 0793-32-5063-20Size: 20 µgDry Ice: NoHazardous: No
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CAT#:0793-32-5063-20Size:20 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Source : Escherichia Coli. TFPI Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 299 amino acids (29-304) and having a molecular mass of 34.3kDa.TFPI is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. TFPI is a protease inhibitor which controls the tissue factor (TF) -dependent pathway of blood coagulation. The coagulation process starts with the creation of a factor VIIa-TF complex, that proteolytically triggers additional proteases (factors IX and X) and eventually results in a fibrin clot. TFPI inhibits the activated factor X and VIIa-TF proteases in an autoregulatory loop. TFPI is glycosylated and predominantly located in the vascular endothelium and plasma in both free forms and complexed with plasma lipoproteins. A number of alternatively spliced transcript variants of this gene have are known, however the full-length nature of several of these variants were not yet established.
Product Name Alternative
Tissue Factor Pathway Inhibitor (Lipoprotein-Associated Coagulation Inhibitor) ||Extrinsic Pathway Inhibitor||Tissue Factor Pathway Inhibitor||anti-convertin||TFPI1||EPI||LACI||TFI.
Purification
Greater than 85.0% as determined by SDS-PAGE.
Components
The TFPI solution (1mg/mL) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea and 10% glycerol.
Storage Conditions
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA) .Avoid multiple freeze-thaw cycles.
Amino Acids
MGSSHHHHHH SSGLVPRGSH MGSDSEEDEE HTIITDTELP PLKLMHSFCA FKADDGPCKA IMKRFFFNIF TRQCEEFIYG GCEGNQNRFE SLEECKKMCT RDNANRIIKT TLQQEKPDFC FLEEDPGICR GYITRYFYNN QTKQCERFKY GGCLGNMNNF ETLEECKNIC EDGPNGFQVD NYGTQLNAVN NSLTPQSTKV PSLFEFHGPS WCLTPADRGL CRANENRFYY NSVIGKCRPF KYSGCGGNEN NFTSKQECLR ACKKGFIQRI SKGGLIKTKR KRKKQRVKIA YEEIFVKNM.

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Alternative Products

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T5576Tissue Factor Pathway Inhibitor
493779TFPI (Tissue Factor Pathway Inhibitor, Tissue Factor Pathway Inhibitor (Lipoprotein-Associated Coagulation Inhibitor) )
GWB-626C0BTissue Factor Pathway Inhibitor Antibody
142499Tissue Factor Pathway Inhibitor (TFPI)
216980TFPI (Tissue Factor Pathway Inhibitor)
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550216Tissue Factor Pathway Inhibitor (Biotin)
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