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Recombinant Human Lamin-A

CAT: 0793-32-4089-10Size: 10 µgDry Ice: NoHazardous: No
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CAT#:0793-32-4089-10Size:10 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Source : Escherichia Coli. Recombinant Human Lamin A produced in E.Coli is a single, non-glycosylated polypeptide chain containing 645 amino acids and having a molecular mass of 70 kDa. Lamin-A is a major component of the nuclear lamina, a dynamic meshwork located just under the nuclear envelope and it is encoded by lamin A/C gene (LMNA) .Lamin-A is synthesized as Prelamin A, a longer precursor that in vivo goes through a serial post-translational modifications that lead to mature Lamin A.Diverse mutations in the Lamin A/C gene are associated with different diseases that are collectively called laminophaties, including Emery-Dreifuss muscular dystrophy, familiar partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome.
Product Name Alternative
Prelamin-A/C||LMNA||LMN1||Lamin-A/C||70 kDa lamin||Renal carcinoma antigen NY-REN-32||FPL||IDC||LFP||CDDC||EMD2||FPLD||HGPS||LDP1||LMNC||PRO1||CDCD1||CMD1A||FPLD2||LMNL1||CMT2B1||LGMD1B.
Purification
Greater than 90.0% as determined by SDS-PAGE.
Components
The Lamin-A Protein solution (0.9mg/mL) contains 20mM phosphate buffer pH 7.0, 500mM NaCl, 1mM DTT, 1.5mM EDTA and 20% (v/v) Glycerol.
Storage Conditions
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Avoid multiple freeze-thaw cycles.

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