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CDKN2C Recombinant Protein

CAT: 0793-32-2968-20Size: 20 µgDry Ice: NoHazardous: No
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CAT#:0793-32-2968-20Size:20 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Source : E.coli. CDKN2C Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 192 amino acids (1-168 and having a molecular mass of 20.7kDa.CDKN2C is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. CDKN2C is a member of the CDKN2 cyclin-dependent kinase inhibitor family. CDKN2C cooperates with CDK4 or CDK6, and inhibits the activation of the CDK kinases, therefore acts as a cell growth regulator which regulates cell cycle G1 progression. CDKN2C suppresses the cell growth and proliferation with a correlated dependency on endogenous retinoblastoma protein RB. Studies in the knockout mice show CDKN2C takes part in regulating spermatogenesis, in addition to suppressing tumorigenesis.
Product Name Alternative
Cyclin-dependent kinase inhibitor 2C (p18 inhibits CDK4) ||cyclin-dependent kinase 4 inhibitor C||cyclin-dependent kinase 6 inhibitor p18||INK4C||p18||p18-INK6||p18-INK4C||CDK6 inhibitor p18||cyclin-dependent inhibitor||CDKN6||p18-INK4c.
Purification
Greater than 95% as determined by SDS-PAGE.
Components
The CDKN2C solution (0.5mg/mL) contains 20mM Tris-HCl buffer (pH 8.0), 200mM NaCl, 2mM DTT and 10% glycerol.
Storage Conditions
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA) .Avoid multiple freeze-thaw cycles.
Amino Acids
MGSSHHHHHH SSGLVPRGSH MGSHMAEPWG NELASAAARG DLEQLTSLLQ NNVNVNAQNG FGRTALQVMK LGNPEIARRL LLRGANPDLK DRTGFAVIHD AARAGFLDTL QTLLEFQADV NIEDNEGNLP LHLAAKEGHL RVVEFLVKHT ASNVGHRNHK GDTACDLARL YGRNEVVSLM QANGAGGATN LQ

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