Anti-CD22 Polyclonal Antibody

CAT: 0793-39-2035-100Size: 100 µg/VialDry Ice: NoHazardous: No

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CAT#:0793-39-2035-100Size:100 µg/Vial

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

CD22 is a surface glycoprotein of B lymphocytes that is rapidly phosphorylated on cytoplasmic tyrosines after antigen receptor cross-linking. CD22 is a negative regulator of antigen receptor signaling whose onset of expression at the mature B cell stage may serve to raise the antigen concentration threshold required for B cell triggering. The human CD22 gene is expressed specifically in B lymphocytes and likely has an important function in cell-cell interactions. The B cell coreceptor CD22 plays an important role in regulating signal transduction via the B cell Ag receptor.3 CD22 is located within the band region q13.1 of chromosome 19.

Product Name Alternative

B-cell receptor CD22; B-lymphocyte cell adhesion molecule; BL-CAM; Sialic acid-binding Ig-like lectin 2; Siglec-2; T-cell surface antigen Leu-14; CD22; CD22; SIGLEC2

Gene Name

CD22

Gene ID

933

UniProt

P20273

Host

Rabbit

Reactivity

Human

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human CD22 (832-847aa ERPQAQENVDYVILKH) .

Target Antigen

B-cell receptor CD22

Clonality

Polyclonal

Applications

WB, IHC-P

Purification

Immunogen affinity purified.

Format

Lyophilized

Components

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. Reconstitute : Add 0.2ml of distilled water will yield a concentration of 500ug/mL.

Storage Conditions

At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time. Avoid repeated freezing and thawing.

Applications Notes

Western blot : 0.1-0.5μg/ml; Immunohistochemistry (Paraffin-embedded Section) : 0.5-1μg/ml

Isotype

Rabbit IgG

UniProtKB · P20273

B-cell receptor CD22

CD22_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: P20273
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: CD22
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: —
Processing: Precursor
Secondary accessions: F5GYU4, F5H7U3, O95699, O95701, O95702, O95703, Q01665, Q32M46, Q92872, Q92873, Q9UQA6, Q9UQA7, Q9UQA8, Q9UQA9, Q9UQB0, Q9Y2A6

Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

Cell adhesion

Cellular component

Cell membraneMembrane

PTM

Disulfide bondGlycoproteinIsopeptide bondPhosphoprotein

Domain

Immunoglobulin domainRepeatSignalTransmembraneTransmembrane helix

Ligand

Lectin

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