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Polyclonal Antibody to OCT1

CAT: 0793-35-1842-50Size: 50 μLDry Ice: NoHazardous: No
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CAT#:0793-35-1842-50Size:50 μL
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Description
Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR By similarity. In case of human herpes simplex virus (HSV) infection, POU2F1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and HCFC1 thereby enabling the transcription of the viral immediate early genes. Prefontaine G.G., Walther R., Giffin W. J. Biol. Chem. 274:26713-26719 (1999) Mahajan S.S., Wilson A.C. Mol. Cell. Biol. 20:919-928 (2000)
Product Name Alternative
1-Oct|| OTF1|| oct-1B
Gene Name
POU2F1
Gene ID
5451
UniProt
P14859
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Peptide sequence around aa.270~274 (T-P-K-R-I) derived from Human Oct-1.
Target Antigen
OCT4
Clonality
Polyclonal
Applications
WB, IF
Format
Purified
Components
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Predicted MW: 90kd, Western blotting: 1:500~1:1000, Immunofluorescence?1:100~1:200
Isotype
Rabbit IgG

UniProtKB · P14859

POU domain, class 2, transcription factor 1

PO2F1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P14859
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
POU2F1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
B1AL91, B1AL93, B4E029, J3KP77, Q5TBT7, Q6PK46, Q8NEU9, Q9BPV1
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Molecular function

ActivatorDNA-binding

Coding sequence diversity

Alternative splicing

Domain

Homeobox

Cellular component

Nucleus

PTM

Phosphoprotein

Biological process

TranscriptionTranscription regulation

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