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Anti-Human IgE APC MAb (Clone :4H10)

CAT: 0793-30-2864-0.1Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0793-30-2864-0.1Size:0.1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Specificity: The mouse monoclonal antibody 4H10 reacts with human IgE; it recognizes an epitope different from the ones recognized by BE5 and 4G7 antibodies to IgE. The epitope is located within the amino acids 267-279 (TWLEDGQVMDVDL) . Immunoglobulin E (IgE) is a 180 kDa soluble protein serving as an antigen-specific unit of mast cell effector mechanisms. IgE has the lowest serum concentration of all immunoglobulins (approximately 0.5 mg/l) in healthy individuals, but upon allergen challenge its concentration in blood increases dramatically. Although biological survival of free IgE is very short (T1/2 = 2 days), it is stabilized after binding to its high affinity receptor. Unlike IgM- IgG- and IgA-committed B cells, IgE-switched B cells do not undergo clonal expansion.
Host
Mouse
Reactivity
Human
Immunogen
Purified human IgE.
Target Antigen
IgE
Clonality
Monoclonal
Clone
4H10
Applications
FACS
Purification
Purified antibody is conjugated with activated allophycocyanin (APC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
Components
0.1 mg/mL Formulation: Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Storage Conditions
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Applications Notes
Flow cytometry: Recommended dilution: 0.5-3 μg/mL
Isotype
Mouse IgG1
Conjugate
APC

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