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Anti-Human CD368 MAb (Clone: 9B9)

CAT: 0793-30-2835-0.1Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0793-30-2835-0.1Size:0.1 mg
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Description
Specificity : The mouse monoclonal antibody 9B9 recognizes an extracellular epitope of CD368, a type II transmembrane protein of C lectin family, expressed mainly on monocytes and neutrophils. Description : CD368 is an approximately 25-30 kDa C-type lectin, which serves as one of pattern recognition receptors of the innate immune system. It recognizes pathogen-associated molecular patterns of bacteria and fungi, such as alpha-mannans or trehalose 6,6 ́-dimycolate, and transfers the signal downstream using associated Fc receptor gamma chain. CD368 is expressed on neutrophils, monocytes, and on some populations of blood dendritic cells, but it decreases during differentiation of monocytes into dendritic cells or macrophages. Increased expression can be induced by IFN-gamma, TNF-alpha, IL-6, and IL-10. CD368 triggering leads to driving of antigen-presenting cells maturation and to promotion of T cell differentiation into Th1 and Th17.
Product Name Alternative
C-type lectin domain family 4 member D, CLEC6, CLEC4D, dectin 3, MCL, MPCL
Gene Name
CLEC4D
Gene ID
338339
UniProt
Q8WXI8
Host
Mouse
Reactivity
Human, Non-Human Primates
Immunogen
CD368 ectodomain fused with human Fc
Target Antigen
CD368
Clonality
Monoclonal
Clone
9B9
Applications
IP, ICC, ELISA, FACS
Purification
Purified by protein-A affinity chromatography.
Components
1 mg/mL Storage Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Storage Conditions
Store at 2-8°C. Do not freeze.
Applications Notes
Flow cytometry: Recommended dilution: 1-5 μg/mL
Isotype
Mouse IgG2b kappa

UniProtKB · Q8WXI8

C-type lectin domain family 4 member D

CLC4D_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q8WXI8
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CLEC4D
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
Q8N5J5
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Biological process

Adaptive immunityImmunityInnate immunity

Ligand

CalciumLectinMetal-binding

Cellular component

Cell membraneMembrane

PTM

Disulfide bondGlycoprotein

Domain

Signal-anchorTransmembraneTransmembrane helix

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Alternative Products

CatalogName
MBS1564556-01Anti-Human CD368/CLEC4D Antibody (9B9)
HV778117-01Anti-Human CD368/CLEC4D Antibody (9B9), FITC
FHJ95013Anti-Human CD368/CLEC4D Antibody (9B9), APC
MBS1585301-01Anti-Human CD368/CLEC4D Antibody (9B9), PE
FHJ95014Anti-Human CD368/CLEC4D Antibody (9B9), PerCP
PTX24089Anti-Human CD368/CLEC4D Monoclonal Antibody (9B9), PE
PTX22863Anti-Human CD368/CLEC4D Monoclonal Antibody (9B9), APC
PTX22250Anti-Human CD368/CLEC4D Monoclonal Antibody (9B9), FITC
PTX23476Anti-Human CD368/CLEC4D Monoclonal Antibody (9B9), PerCP
GT14214PE anti-human CD368 (CLEC4D)

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