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Polyclonal antibody to BAG2

CAT: 0793-20-1017-50Size: 50 μLDry Ice: NoHazardous: No
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CAT#:0793-20-1017-50Size:50 μL
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Description
The BAG proteins are a family of chaperone regulators that modulate a number of diverse processes including proliferation, survival, stress responses, tumorigenesis, neuronal differentiation, growth arrest and. BAG proteins have been characterized as co-chaperones and interact with the chaperone heat shock proteins 70, both constitutive Hsc70 and inducible Hsp70. BAG proteins bind through their BAG domain to the ATPase domain of Hsc70/Hsp70, and can modulate either positively or negatively the functions of the Hsc70/Hsp70 chaperone proteins.The BAG domain has been shown to contribute to the anti-apoptotic activity of BAG- family proteins. The anti-apoptotic activities of BAG-family proteins may be dependent on their interactions with Hsc70/Asp70 and/or binding to Bcl-2. In addition to the conserved BAG domain, BAG-family proteins also contain additional domains which enable them to interact with specific target proteins or to target them to specific locations within cells. The BAG family contains at least six family members, including BAG-1 and its various isoforms [including BAG-1S, BAG-1M (RAP46/HAP46), and BAG-1L, BAG2, BAG3 (CAIR-1; Bis, ), BAG4 (SODD), BAG5 and BAG6 (Scythe, BAT3) .
Product Name Alternative
BAG2
Gene Name
BAG2
Gene ID
9532
UniProt
O95816
Host
Rabbit
Reactivity
Human
Immunogen
A full-length recombinant protein of human BAG2 was used as the immunogen for this antibody
Target Antigen
BAG2
Clonality
Polyclonal
Applications
WB, IHC, IP
Format
Sera
Components
50 μl sera
Storage Conditions
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
WB: 1:1000-1:2000, IHC (paraffin) : 1:1000-1:5000, IHC (frozen) : Users should optimize, IP: 1:50-1:200
Isotype
Rabbit IgG

UniProtKB · O95816

BAG family molecular chaperone regulator 2

BAG2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O95816
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
BAG2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
BAG-2
EC number
—
Processing
—
Secondary accessions
B4DXE2, Q08AS9, Q6FID0
Protein keywords

PTM

AcetylationPhosphoprotein

Coding sequence diversity

Alternative splicing

Molecular function

Chaperone

Domain

Coiled coil

Technical term

Proteomics identificationReference proteome

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