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Polyclonal Antibody to APH1A

CAT: 0793-11-10036-100Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0793-11-10036-100Size:100 µg
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Description
APH1A also known as Anterior pharynx-defective 1, is a multi-spanning membrane protein and an integral component of the high molecular weight gamma-secretase complex that also contains presenilin, nicastrin, and Pen-2. The gamma-secretase complex is required for the intramembrane proteolysis of APP (amyloid-beta precursor protein) and Notch. APH1A is essential for gamma-cleavage of APP to enable the intracellular domain to travel to the nucleus. APH1A satisfies three major criteria for a subunit of the gamma-secretase complex in mammalian cells. First, endogenous APH1A, nicastrin, and the presenilin NTF:CTF heterodimers physically interact with each other in vivo and under the conditions that are compatible with gamma-secretase activity. Second, like presenilin and nicastrin, APH1A is required for the intramembrane proteolysis of both APP and Notch. Third, the down-regulation of APH1A like presenilin or nicastrin leads to concurrent reduction of the mature nicastrin or the steady-state levels of the presenilin endoproteolytic fragments, the mature presenilin species within the gamma-secretase complex.
Product Name Alternative
APH1A||PSF||CGI-78||UNQ579/PRO1141
Gene Name
APH1A
Gene ID
51107
UniProt
Q96BI3
Host
Rabbit
Reactivity
Human
Immunogen
A partial length recombinant APH1A protein (amino acids 11-245) was used as the immunogen for this antibody.
Target Antigen
APH1A
Clonality
Polyclonal
Applications
WB
Purification
Protein A Chromatography
Format
Purified
Components
25 μg in 50 μl/100 μg in 200 μl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage Conditions
Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Western blot analysis: 1-2 μg/mL
Isotype
Rabbit IgG

UniProtKB · Q96BI3

Gamma-secretase subunit APH-1A

APH1A_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q96BI3
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
APH1A
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
APH-1a
EC number
—
Processing
—
Secondary accessions
B4DQK0, Q5TB22, Q5TB23, Q969R6, Q9BVG0, Q9Y386
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Cellular component

Endoplasmic reticulumGolgi apparatusMembrane

Biological process

Notch signaling pathway

Domain

TransmembraneTransmembrane helix

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