Polyclonal Antibody to Endoglin

CAT: 0793-11-7552-100Size: 100 µgDry Ice: NoHazardous: No

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CAT#:0793-11-7552-100Size:100 µg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

ENG (Endoglin) is an integral membrane glycoprotein that serves as a co receptor for members of the transforming growth factor-beta superfamily of proteins. It is a type I membrane glycoprotein expressed as a disulfide-linked homodimer on human vascular endothelial cells and is implicated in a dominant vascular dysplasia known as hereditary hemorrhagic telangiectasia as well as in preeclampsia. Endoglin suppresses human prostate cancer (PCa) cell invasion. It has been identified as a candidate tumor-suppressor gene in esophageal squamous cell carcinoma (ESCC) .

Product Name Alternative

ENG||END

Gene Name

ENG

Gene ID

2022

UniProt

P17813

Host

Rabbit

Reactivity

Human

Immunogen

A partial length recombinant Endoglin protein (amino acids 43-287) was used as the immunogen for this antibody.

Target Antigen

Endoglin

Clonality

Polyclonal

Applications

Purification

Protein A Chromatography

Format

Purified

Components

25 μg in 50 μl/100 μg in 200 μl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.

Storage Conditions

Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles.

Applications Notes

Western blot analysis: 2-4 μg/mL

Isotype

Rabbit IgG

UniProtKB · P17813

Endoglin

EGLN_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: P17813
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: ENG
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: —
Processing: Precursor
Secondary accessions: Q14248, Q14926, Q5T9C0

Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

AngiogenesisCell adhesion

Cellular component

Cell membraneMembrane

Disease

Disease variant

PTM

Disulfide bondGlycoproteinPhosphoprotein

Domain

SignalTransmembraneTransmembrane helix

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GTR18043529-01	Endoglin polyclonal antibody
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