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Polyclonal Antibody to CD11C

CAT: 0793-11-7547-25Size: 25 µgDry Ice: NoHazardous: No
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CAT#:0793-11-7547-25Size:25 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CD11c/CD18 is a monocyte/macrophage-enriched integrin that has been reported to bind to a variety of ligands. These include cell surface proteins (LPS, ICAM-1, ICAM-2, ICAM-4 and VCAM-1), extracellular matrix proteins (collagen I), and soluble ligands (iC3b, heparin and fibrinogen) . It is expressed in macrophages, monocytes, granulocytes, subsets of T and B cells, and dendritic cells. CD11c functions as a cell surface receptor for numerous soluble factors and proteins. The interaction mediates leukocyte interactions with other cell types and is a signal transducing receptor. It is found primarily on myeloid cells, where its expression is regulated both during differentiation and during monocyte maturation into tissue macrophages.
Product Name Alternative
ITGAX||CD11C
Gene Name
ITGAX
Gene ID
3687
UniProt
P20702
Host
Rabbit
Reactivity
Human
Immunogen
A partial length recombinant CD11c protein (amino acids 620-835) was used as the immunogen for this antibody.
Target Antigen
CD11C
Clonality
Polyclonal
Applications
WB
Purification
Protein A Chromatography
Format
Purified
Components
25 μg in 50 μl/100 μg in 200 μl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage Conditions
Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Western blot analysis: 1-2 μg/mL
Isotype
Rabbit IgG

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