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Polyclonal Antibody to VAV2

CAT: 0793-11-4056-25Size: 25 µgDry Ice: NoHazardous: No
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CAT#:0793-11-4056-25Size:25 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Vav2 is a member of the Vav family that serves as a GRF (guanine nucleotide exchange factor) for the Rho family of Ras-related GTPases. It is widely expressed and regulates processes including cell migration, neuronal development and phagocytosis through interactions with different proteins. Vav2, a GEF for Rac1, RhoA, and Cdc42, is shown to be regulated by a phosphorylation-dependent interaction with PKL (Paxillin kinase linker) . PKL is required for Vav2 activation downstream of integrin engagement and epidermal growth factor (EGF) stimulation. During the process of spinal neurons, the Vav2 activity is necessary for optimal neurite outgrowth and promotes branching by targeting GEF activity to branch points.
Product Name Alternative
VAV2
Gene Name
VAV2
Gene ID
7410
UniProt
P52735
Host
Rabbit
Reactivity
Human
Immunogen
A partial length recombinant VAV2 protein (amino acids 610-824) was used as the immunogen for this antibody.
Target Antigen
VAV2
Clonality
Polyclonal
Applications
WB
Purification
Protein A Chromatography
Format
Purified
Components
25 μg in 50 μl/100 μg in 200 μl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage Conditions
Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Western blot analysis: 1-2 μg/mL
Isotype
Rabbit IgG

UniProtKB · P52735

Guanine nucleotide exchange factor VAV2

VAV2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P52735
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
VAV2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
VAV-2
EC number
—
Processing
—
Secondary accessions
A2RUM4, A8MQ12, B6ZDF5, Q5SYV3, Q5SYV4, Q5SYV5, Q6N012, Q6PIJ9, Q6Q317
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

Angiogenesis

Molecular function

Guanine-nucleotide releasing factor

Ligand

Metal-bindingZinc

PTM

Phosphoprotein

Domain

RepeatSH2 domainSH3 domainZinc-finger

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