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Polyclonal Antibody to RAGE

CAT: 0793-11-4029-100Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0793-11-4029-100Size:100 µg
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Description
RAGE (Advanced glycosylation end product-specific receptor) is a member of immunoglobulin superfamily with multiple isoforms being located on the membrane of endothelial cells. RAGE acts transporter of amyloid beta peptide across the blood brain barrier. It has also been reported that RAGE is overexpressed in Alzheimer disease. RAGE is also involved in vascular inflammation in atherosclerosis, type 2 diabetes mellitus. High levels of RAGE protein is found in brain tissue.
Product Name Alternative
AGER||RAGE
Gene Name
AGER
Gene ID
177
UniProt
Q15109
Host
Rabbit
Reactivity
Human
Immunogen
A partial length recombinant RAGE protein (amino acids 1-280) was used as the immunogen for this antibody.
Target Antigen
RAGE
Clonality
Polyclonal
Applications
WB
Purification
Protein A Chromatography
Format
Purified
Components
25 μg in 50 μl/100 μg in 200 μl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage Conditions
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Western blot analysis: 1-2μg/mL
Isotype
Rabbit IgG

UniProtKB · Q15109

Advanced glycation end product-specific receptor

RAGE_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q15109
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
AGER
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
A2BFI7, A6NKF0, A7Y2U9, B0V176, Q15279, Q3L1R4, Q3L1R5, Q3L1R6, Q3L1R7, Q3L1R8, Q3L1S0, Q86SN1, Q9H2X7, Q9Y3R3, V5R6A3
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Cellular component

Cell membraneCell projectionEndosomeMembraneNucleusSecreted

PTM

Disulfide bondGlycoproteinPhosphoproteinUbl conjugation

Biological process

DNA damageDNA repairDNA replicationInflammatory responsePhagocytosis

Molecular function

DNA-bindingReceptorRNA-binding

Domain

Immunoglobulin domainRepeatSignalTransmembraneTransmembrane helix

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