Polyclonal ACE2 antibody

CAT: 0793-11-2006-25Size: 25 µgDry Ice: NoHazardous: No
CAT#:0793-11-2006-25Size:25 µg
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Description
Angiotensin-converting enzyme2 (ACE2) is an ectoenzyme (carboxypeptidase) with an extracellular catalytic domain that predominantly localizes at the plasma membrane and is thereby able to hydrolyze circulating peptides. ACE2 has approximately 42% sequence identity with ACE, and its cytoplasmic and transmembrane domains show 48% homology to the protein collectrin that plays a critical role in the amino acid absorption of the kidney. ACE2 converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. ACE2 is involved in the regulation of systemic blood pressure and has direct effects on cardiac functions. It is expressed predominantly in endothelial cells of the lung, gut, heart and kidney. ACE2 together with the protease TMPRSS2 acts as a functional receptor for SARS coronavirus as well as for the new highly pathogenic coronavirus, 2019-nCoV/SARS-CoV-2, which is cause for pneumonia COVID-19.
Product Name Alternative
Angiotensin-converting enzyme homolog, Angiotensin-converting enzyme-related carboxypeptidase, Metalloprotease MPROT15
Gene Name
ACE2
Gene ID
59272
UniProt
Q9BYF1
Host
Rabbit
Immunogen
A partial length recombinant ACE2 protein (amino acids 507-678) was used as the immunogen for this antibody.
Target Antigen
ACE2
Clonality
Polyclonal
Applications
ELISA, WB
Purification
Protein A Chromatography
Format
Purified
Components
25 μg in 50 μl/100 μg in 200 μl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage Conditions
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Recommended dilutions: WB: 05-1 μg/mL. However, this need to be optimized based on the research applications.
Isotype
Rabbit IgG

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