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CCG273441

CAT: 0804-HY-47573-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-47573-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CCG273441 is a covalent inhibitor of G protein-coupled receptor (GPCR) kinase 5 (GRK5) with an IC50 value of 3.8 nM. CCG273441 is highly selective to GRK5 over GRK2 (IC50=4.8 μM) by binding Cys474, a GRK5 subfamily-specific residue, as a covalent handle[1].
CAS Number
2750414-35-6
UNSPSC
12352005
Target
G Protein-coupled Receptor Kinase (GRK)
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/ccg273441.html
Purity
98.78
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(/C(C1=C2)=C\C3=C(C(NC(CCl)=O)=C(N3)C)C)NC1=CC=C2C(N[C@@H](C4=CC=C(C=C4)F)C)=O
Molecular Formula
C26H24ClFN4O3
Molecular Weight
494.95
References & Citations
[1]Rowlands RA, et al. Generation of Highly Selective, Potent, and Covalent G Protein-Coupled Receptor Kinase 5 Inhibitors. J Med Chem. 2021 Jan 14;64 (1) :566-585.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
GRK2

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