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Nociceptin (1-7)

CAT: 0804-HY-P1319Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-P1319Size:1 Each
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Description
Nociceptin (1-7) is the N-terminal bioactive fragment of nociceptin. Nociceptin (1-7) is a potent ORL1 (NOP) receptor agonist with antinociceptive activity. Nociceptin (1-7) combines with nociceptin reduces hyperalgesia in vivo[1].
CAS Number
178249-42-8
UNSPSC
12352209
Target
Opioid Receptor
Type
Peptides
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/nociceptin-1-7.html
Solubility
10 mM in DMSO
Smiles
C[C@@H](C(O)=O)NC(CNC([C@H]([C@H](O)C)NC([C@H](CC1=CC=CC=C1)NC(CNC(CNC([C@H](CC2=CC=CC=C2)N)=O)=O)=O)=O)=O)=O
Molecular Formula
C31H41N7O9
Molecular Weight
655.70
References & Citations
[1]T Sakurada, et al. Nociceptin (1 - 7) antagonizes nociceptin-induced hyperalgesia in mice.Br J Pharmacol. 1999 Nov;128 (5) :941-4.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
NOP Receptor/ORL1

Chemical Information

Nociceptin (1-7)
CAS Number178249-42-8
PubChem CID71353398
IUPAC Name(2S)-2-[[2-[[(2S,3R)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-phenylpropanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]propanoic acid
Molecular FormulaC31H41N7O9
Molecular Weight655.7
XLogP-3.3
Topological Polar Surface Area258
Hydrogen Bond Donor Count9
Hydrogen Bond Acceptor Count10
Rotatable Bond Count18
Heavy Atom Count47
Formal Charge0
Complexity1090
SMILES
C[C@H]([C@@H](C(=O)NCC(=O)N[C@@H](C)C(=O)O)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)CNC(=O)CNC(=O)[C@H](CC2=CC=CC=C2)N)O
InChI
InChI=1S/C31H41N7O9/c1-18(31(46)47)36-25(41)17-35-30(45)27(19(2)39)38-29(44)23(14-21-11-7-4-8-12-21)37-26(42)16-33-24(40)15-34-28(43)22(32)13-20-9-5-3-6-10-20/h3-12,18-19,22-23,27,39H,13-17,32H2,1-2H3,(H,33,40)(H,34,43)(H,35,45)(H,36,41)(H,37,42)(H,38,44)(H,46,47)/t18-,19+,22-,23-,27-/m0/s1
InChIKey
KVTLKXLQUDUFSD-FLSSTNBBSA-N
Chemical Structure
2D Structure
2D structure of Nociceptin (1-7)
CAS: 178249-42-8
CID: 71353398
Formula: C31H41N7O9
MW: 655.7
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight655.7
XLogP3-3.3
Hydrogen Bond Donor Count9
Hydrogen Bond Acceptor Count10
Rotatable Bond Count18
Exact Mass655.29657591
Monoisotopic Mass655.29657591
Topological Polar Surface Area258 Ų
Heavy Atom Count47
Formal Charge0
Complexity1090
Isotope Atom Count0
Defined Atom Stereocenter Count5
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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HY-P0183-01Nociceptin
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HY-P1320A[Nphe1]Nociceptin (1-13) NH2 (TFA)
HY-P1300[ (pF) Phe4]Nociceptin (1-13) NH2
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HY-P0192[Phe1Ψ (CH2-NH) Gly2]Nociceptin (1-13) NH2

Alternative Products

CatalogName
B5087-1Nociceptin (1-7)
T75908-01Nociceptin (1-7) TFA
MBS5773317Nociceptin (1-7) acetate
021-67Orphanin FQ (1-7) / Nociceptin (1-7) (Human, Rat, Mouse, Ox)
MBS3612254-01Nociceptin(1-13), amide
MBS5763808Nociceptin (1-13), amide
GTR18890222Nociceptin (1-13) peptide
B5102-1Nociceptin (1-13)NH2
CCP2681-01Nociceptin (1-13) amide
CCP1352-01Nociceptin

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