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Vorinostat

CAT: 0804-HY-10221-01Size: 250 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-10221-01Size:250 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Vorinostat (SAHA) is a potent and orally active pan-inhibitor of HDAC1, HDAC2 and HDAC3 (Class I), HDAC6 and HDAC7 (Class II) and HDAC11 (Class IV), with ID50 values of 10 nM and 20 nM for HDAC1 and HDAC3, respectively. Vorinostat induces cell apoptosis[1][4]. Vorinostat is also an effective inhibitor of human papillomaviruse (HPV) -18 DNA amplification[7].
CAS Number
149647-78-9
Product Name Alternative
SAHA; Suberoylanilide hydroxamic acid
UNSPSC
12352005
Hazard Statement
H341, H360
Target
Apoptosis; Autophagy; Filovirus; HDAC; HPV; Mitophagy
Type
Reference compound
Related Pathways
Anti-infection; Apoptosis; Autophagy; Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/Vorinostat.html
Purity
99.96
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C(NC1=CC=CC=C1)CCCCCCC(NO)=O
Molecular Formula
C14H20N2O3
Molecular Weight
264.32
Precautions
H341, H360
References & Citations
[1]Hrzenjak A et al. Histone deacetylase inhibitor vorinostat suppresses the growth of uterine sarcomas in vitro and in vivo. Mol Cancer. 2010 Mar 4;9:49.|[2]Lautz TB, et al. The effect of vorinostat on the development of resistance to NSC 123127 in neuroblastoma. PLoS One. 2012;7 (7) :e40816.|[3]Richon VM, et al. A class of hybrid polar inducers of transformed cell differentiation inhibits histone deacetylases. Proc Natl Acad Sci U S A. 1998 Mar 17;95 (6) :3003-7.|[4]Xu WS, et al. Histone deacetylase inhibitors: molecular mechanisms of action. Oncogene. 2007 Aug 13;26 (37) :5541-52.|[5]Pérez-Cañamás A, et al. Sphingomyelin-induced inhibition of the plasma membrane calcium ATPase causes neurodegeneration in type A Niemann-Pick disease. Mol Psychiatry. 2017 May;22 (5) :711-723.|[6]Wang J, et al. Snail determines the therapeutic response to mTOR kinase inhibitors by transcriptional repression of 4E-BP1. Nat Commun. 2017 Dec 20;8 (1) :2207.|[7]Banerjee NS, et al. Vorinostat, a pan-HDAC inhibitor, abrogates productive HPV-18 DNA amplification. Proc Natl Acad Sci U S A. 2018 Nov 20;115 (47) :E11138-E11147.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
HDAC1; HDAC11; HDAC2; HDAC3; HDAC7

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