Bivamelagon

Chemical Information
Bivamelagon is an orally bioavailable agonist of melanocortin-4 receptor (MC4R), with potential appetite suppressant activity that can potentially be used in the treatment of hypothalamic obesity. Upon oral administration, bivamelagon selectively targets, binds to and activates MC4R in the brain. This activates the MC4R-mediated signaling pathway and may suppress appetite, decrease caloric intake, increase energy expenditure, decrease weight gain and promote weight loss. MC4 receptors in the brain are involved in regulation of hunger, satiety, and energy expenditure.
| CAS Number | 2641595-54-0 |
| PubChem CID | 165152355 |
| IUPAC Name | N-[(3S,5S)-1-[(3S,4R)-1-tert-butyl-4-(4-chlorophenyl)pyrrolidine-3-carbonyl]-5-(morpholine-4-carbonyl)pyrrolidin-3-yl]-2-methyl-N-(4-methylcyclohexyl)propanamide |
| Molecular Formula | C35H53ClN4O4 |
| Molecular Weight | 629.3 |
| XLogP | 4.9 |
| Topological Polar Surface Area | 73.4 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 5 |
| Rotatable Bond Count | 7 |
| Heavy Atom Count | 44 |
| Formal Charge | 0 |
| Complexity | 1010 |
| Property | Value |
|---|---|
| Molecular Weight | 629.3 |
| XLogP3 | 4.9 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 5 |
| Rotatable Bond Count | 7 |
| Exact Mass | 628.3755339 |
| Monoisotopic Mass | 628.3755339 |
| Topological Polar Surface Area | 73.4 Ų |
| Heavy Atom Count | 44 |
| Formal Charge | 0 |
| Complexity | 1010 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 4 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
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