Topotecan (hydrochloride) (Standard)

Topotecan (hydrochloride) (Standard)

• CAS Number: 119413-54-6
• UNSPSC Description: Topotecan (hydrochloride) (Standard) is the analytical standard of Topotecan (hydrochloride). This product is intended for research and analytical applications. Topotecan Hydrochloride (SKF 104864A Hydrochloride) is a Topoisomerase I inhibitor with potent antineoplastic activities.
• Target Antigen: Apoptosis; Autophagy; Topoisomerase
• Type: Reference Standards
• Related Pathways: Apoptosis;Autophagy;Cell Cycle/DNA Damage
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/topotecan-hydrochloride-standard.html
• Smiles: [H]Cl.O=C1[C@](O)(CC)C2=C(CO1)C(N3CC4=CC5=C(CN(C)C)C(O)=CC=C5N=C4C3=C2)=O
• Molecular Weight: 457.91
• References & Citations: [1]Zhang FL, et al. PLoS One. 2013 Nov 26;8(11):e81815.Topoisomerase I inhibitors, Shikonin and Topotecan, inhibit growth and induce apoptosis of glioma cells andglioma stem cells.|[2]Kumar S, et al. Metronomic oral topotecan with pazopanib is an active antiangiogenic regimen in mouse models of aggressive pediatric solid tumor. Clin Cancer Res. 2011 Sep 1;17(17):5656-67.
• Shipping Conditions: Room temperature