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KIN-8194

CAT: 0804-HY-15805-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-15805-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
KIN-8194 is an orally active dual inhibitor of HCK and BTK, with IC50 values of 0.915 and [1][2].
CAS Number
330786-01-1
UNSPSC
12352005
Target
Btk; Src
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/kin-8194.html
Purity
98.01
Solubility
10 mM in DMSO
Smiles
NC1=NC=NC2=C1C(C3=CC=C(OC4=CC=CC=C4)C=C3)=NN2[C@H]5CC[C@H](N6CCN(C)CC6)CC5
Molecular Formula
C28H33N7O
Molecular Weight
483.61
References & Citations
[1]Lantermans HC, et al. The dual HCK/BTK inhibitor KIN-8194 impairs growth and integrin-mediated adhesion of BTKi-resistant mantle cell lymphoma. Leukemia. 2024 Mar 7. |[2]Yang G, et al. The HCK/BTK inhibitor KIN-8194 is active in MYD88-driven lymphomas and overcomes mutated BTKCys481 ibrutinib resistance. Blood. 2021 Nov 18;138 (20) :1966-1979.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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