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HET0016

CAT: 0804-HY-124527-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-124527-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HET0016 is a potent and selective 20-hydroxyeicosatetraenoic acid (20-HETE) synthase inhibitor, with IC50 values of 17.7 nM, 12.1 nM and 20.6 nM for recombinant CYP4A1-, CYP4A2- and CYP4A3-catalyzed 20-HETE synthesis, respectively. HET0016 also is a selective CYP450 inhibitor, which has been shown to inhibit angiogenesis and tumor growth[1][2].
CAS Number
339068-25-6
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Cytochrome P450
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/het0016.html
Purity
99.69
Solubility
DMSO : 5 mg/mL (ultrasonic)
Smiles
CCCCC1=CC=C(C(C)=C1)/N=C/NO
Molecular Formula
C12H18N2O
Molecular Weight
206.28
Precautions
H315, H319, H335
References & Citations
[1]Seki T, et al. Cytochrome P450 4A isoform inhibitory profile of N-hydroxy-N'- (4-butyl-2-methylphenyl) -formamidine (HET0016), a selective inhibitor of 20-HETE synthesis. Biol Pharm Bull. 2005 Sep;28 (9) :1651-4.|[2]Borin TF, et al. HET0016 decreases lung metastasis from breast cancer in immune-competent mouse model. PLoS One. 2017 Jun 13;12 (6) :e0178830.|[3]Liu Y, et al. The protective effect of HET0016 on brain edema and blood-brain barrier dysfunction after cerebral ischemia/reperfusion. Brain Res. 2014 Jan 28;1544:45-53.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CYP4

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