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Anti-Basic Fibroblast growth factor (Basic FGF) Antibody

CAT: 1548-S-008-100Size: 100 µLDry Ice: NoHazardous: No
CAT#:1548-S-008-100Size:100 µL
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Fibroblast growth factors (FGFs), a heparin binding growth factor, exhibit widespread mitogenic and neurotrophic activities in a variety of different cells including mesenchymal, neuroectodermal and endothelial cells. aFGF (FGF-1) and bFGF (FGF-2) are present in relatively high levels in CNS. aFGF is expressed by a subset of neuronal populations, while bFGF is expressed by astrocytes, both lack signal peptides. Human bFGF is a 17.2 kDa protein containing 155 amino acid residues. FUNCTION: The heparin-binding growth factors are angiogenic agents in vivo and are potent mitogens for a variety of cell types in vitro. There are differences in the tissue distribution and concentration of these 2 growth factors. SUBUNIT: Monomer. Interacts with CSPG4 and FGFBP1. Found in a complex with FGFBP1, FGF1 and FGF2. MISCELLANEOUS: This protein binds heparin more strongly than does aFGF. SIMILARITY: Belongs to the heparin-binding growth factors family.
Description
Our Anti-Basic Fibroblast growth factor (Basic FGF) sheep polyclonal primary antibody detects human, mouse, and rat Basic Fibroblast growth factor (Basic FGF), and is whole serum. It is validated for use in IHC-Frozen, WB.
Short Description
Our Anti-Basic Fibroblast growth factor (Basic FGF) sheep polyclonal primary antibody detects human, mouse, and rat Basic Fibroblast growth factor (Basic FGF), and is whole serum. It is validated for use in IHC-Frozen, WB.
Synonyms
Heparin-binding growth factor 2; HBGF-2; Basic fibroblast growth factor; bFGF; Prostatropin; FGF2; FGFB
UniProt
P09038
Reactivity
Human, Mouse, and Rat
Immunogen
Recombinant human basic FGF
Target
Basic Fibroblast growth factor (Basic FGF)
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
IHC-Frozen, WB
Format
Whole serum
Precautions
For research use only.
Shipping Conditions
25°C (ambient)
Storage Conditions
Spin vial briefly before opening. Reconstitute in 100 μL sterile-filtered, ultrapure water. Centrifuge to remove any insoluble material. After reconstitution keep aliquots at -20°C for a higher stability, and at 2-8°C with an appropriate antibacterial agent. Glycerol (1:1) may be added for an additional stability. Avoid repetitive freeze/thaw cycles.
IHC Dilution
1:1000-1:2000
WB Dilution
1:1000-1:2000
Specificity
A high level of specificity for bFGF was shown by immunohistochemistry for this antiserum. This antibody is known to react with human, mouse and rat basic FGF.
Host or Source
Sheep
Physical Properties
Lyophilized
Isotype
Mixed
Immunogen Species
Human

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