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RO5166017

CAT: 0804-HY-12699-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-12699-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
RO5166017 is an orally active and species-crosses TAAR1 agonist, with Ki values of 1.9 nM, 2.7 nM, 31 nM and 24 nM for mouse, rat, human and cynomolgus monkey, respectively[1].
CAS Number
1048346-74-2
UNSPSC
12352005
Hazard Statement
H302
Target
Trace Amine-associated Receptor (TAAR)
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/ro5166017.html
Purity
99.37
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
CCN(C1=CC=CC=C1)C[C@@H]2N=C(N)OC2
Molecular Formula
C12H17N3O
Molecular Weight
219.29
Precautions
H302
References & Citations
[1]Florent G Revel, et al. TAAR1 activation modulates monoaminergic neurotransmission, preventing hyperdopaminergic and hypoglutamatergic activity. Proc Natl Acad Sci U S A|[2]Justin N Siemian, et al. Trace amine-associated receptor 1 agonists RO5263397 and RO5166017 attenuate quinpirole-induced yawning but not hypothermia in rats. Behav Pharmacol. 2017 Oct;28 (7) :590-593.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TAAR1

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CatalogName
M34696-01RO5166017

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