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Urelumab Biosimilar - Research Grade

CAT: 1148-ICH5015-25mgSize: 25 mgDry Ice: NoHazardous: No
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CAT#:1148-ICH5015-25mgSize:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
RUO urelumab is a humanized agonistic monoclonal antibody targeting 4-1BB with potential immunostimulatory and antineoplastic activities. Urelumab specifically binds to and activates CD137-expressing immune cells, stimulating an immune response, in particular a cytotoxic T cell response, against tumor cells. .
Product Name Alternative
4-1BB ligand receptor, T-cell antigen 4-1BB, Tnfrsf9, Ila, Ly63, CD137
UniProt
Q07011
Reactivity
Human
Target
4-1BB
Isotype
IgG1
Sequence
https://www.imgt.org/mAb-DB/
Applications
Functional Assays
Purification Method
This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
Concentration
5mg/mL
Endotoxin
≤ 1.0 EU/mg as determined by the LAL method
Purity
>95% by SDS-PAGE
Buffer
ICH3002
References & Citations
Lee et al. A CRISPR activation screen identifies MUC-21 as critical for resistance to NK and T cell-mediated cytotoxicity. Journal of Experimental & Clinical Cancer Research
Shipping Conditions
Blue ice
Storage Conditions
This biosimilar is stable when stored at 2-8°C. For longer term storage (> 3 months) it is recommended to store this antibody at -20°C or -70°C.
Specificity
Detects human CD137. This non-therapeutic antibody uses the same sequence as the therapeutic antibody Urelumab.
Formulation
Sterile, preservative-free, solution in PBS. BSA and Azide free.
Applications Notes
This biosimilar is for research use only (RUO) : it is not for diagnostic or therapeutic procedures and cannot be purchased by patients.
Isotype Control
Bulk Human IgG1 Isotype Control (IB1) [ICH2254]

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