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Toripalimab Biosimilar - Research Grade

CAT: 1148-ICH5002-25mgSize: 25 mgDry Ice: NoHazardous: No
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CAT#:1148-ICH5002-25mgSize:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Pembrolizumab biosimilar is a humanized monoclonal antibody that blocks the interaction between PD-1 and its ligands, PD-L1 and PD-L2. It is an IgG4 kappa immunoglobulin with an approximate molecular weight of 149 kDa.
Product Name Alternative
Programmed cell death protein 1, Pdcd1, CD279
UniProt
Q15116
Host
Humanized
Reactivity
Human
Target
PD-1
Isotype
IgG4
Sequence
https://www.imgt.org/mAb-DB/
Applications
Functional Assays
Purification Method
This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
Concentration
1.0 - 5.0 mg/mL
Endotoxin
<1EU/mg Determined by LAL gel clotting assay
Purity
>95% by SDS-PAGE and HPLC
Buffer
ICH3002
Shipping Conditions
Blue ice
Storage Conditions
Stable for at least one week when stored sterile at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at –80°C. Avoid Repeated Freeze Thaw Cycles.
Specificity
Detects human PD-1. This non-therapeutic antibody uses the same sequence as the therapeutic antibody Toripalimab.
Formulation
Phosphate buffered saline (PBS) pH 7.2, with no carrier protein, potassium or preservatives added. BSA and Azide free.
Applications Notes
This biosimilar is for research use only (RUO) : it is not for diagnostic or therapeutic procedures and cannot be purchased by patients.
Isotype Control
Bulk Human IgG4 Isotype Control (IB4) [ICH2257]

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