Anti-RYK Antibody

CAT: 0519-M07225-50ulSize: 50 µLDry Ice: NoHazardous: No

1 / 1

CAT#:0519-M07225-50ulSize:50 µL

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

Quick Request Actions

Background

May be a coreceptor along with FZD8 of Wnt proteins, such as WNT1, WNT3, WNT3A and WNT5A. Involved in neuron differentiation, axon guidance, corpus callosum establishment and neurite outgrowth. In response to WNT3 stimulation, receptor C- terminal cleavage occurs in its transmembrane region and allows the C-terminal intracellular product to translocate from the cytoplasm to the nucleus where it plays a crucial role in neuronal development.

Description

Boster Bio Anti-RYK Antibody (Catalog # M07225) . Tested in WB, Flow Cytometry application (s) . This antibody reacts with Human.

Synonyms

Tyrosine-protein kinase RYK, 2.7.10.1, RYK, JTK5A

Gene Name

RYK

UniProt

P34925

Host

Mouse

Reactivity

Human

Immunogen

This RYK antibody is generated from a mouse immunized with a KLH conjugated synthetic peptide between 260-565 amino acids from human RYK.

Clonality

Monoclonal

Clone

Clone: 1671CT575.42.61

Tissue Specificity

Observed in all the tissues examined.

Applications

WB, Flow Cytometry

Field of Research

Signal Transduction, Stem Cells

Purification

This antibody is purified through a protein G column, followed by dialysis against PBS.

Function

May be a coreceptor along with FZD8 of Wnt proteins, such as WNT1, WNT3, WNT3A and WNT5A. Involved in neuron differentiation, axon guidance, corpus callosum establishment and neurite outgrowth. In response to WNT3 stimulation, receptor C-terminal cleavage occurs in its transmembrane region and allows the C-terminal intracellular product to translocate from the cytoplasm to the nucleus where it plays a crucial role in neuronal development.

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Observed Molecular Weight

67815 Da

Subcellular Location

Membrane; Single-pass type I membrane protein. Nucleus. Cytoplasm. Note=In cells that have undergone neuronal differentiation, the C-terminal cleaved part is translocated from the cytoplasm to the nucleus.

Isotype

IgG1, k

Contents

Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

UniProtKB · P34925

Inactive tyrosine-protein kinase RYK

RYK_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: P34925
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: RYK
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: H-Ryk
EC number: —
Processing: Precursor
Secondary accessions: A0A087WUK1, A0A096LNL3, Q04696

Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Cellular component

Cell membraneCytoplasmMembraneNucleus

PTM

Disulfide bondGlycoprotein

Molecular function

Receptor

Domain

SignalTransmembraneTransmembrane helix

Biological process

Wnt signaling pathway

Related Products

Catalog	Name
A07225	Anti-Tyrosine-protein kinase RYK RYK Antibody
M07225-1	Anti-RYK Rabbit Monoclonal Antibody
M07225-1-carrier-free	Anti-RYK Rabbit Monoclonal Antibody, Carrier-free
PROTP34925	RYK (NM_002958) Human Recombinant Protein
LS006259-20ug	RYK (NM_001005861) Human Over-expression Lysate
LS006259	RYK (NM_001005861) Human Over-expression Lysate
LS006259-100ug	RYK (NM_001005861) Human Over-expression Lysate
A09597-2	Anti-ANT4/SLC25A31 Antibody
A09597-2-carrier-free	Anti-ANT4/SLC25A31 Antibody
A09597-1	Anti-ANT4 SLC25A31 Antibody

Alternative Products

Catalog	Name
PAab07548	Anti-RYK antibody
SLM-51489M-01	Mouse Anti-RYK antibody
RHE05603	Anti-RYK Antibody (R1U81)
RHE05602	Anti-RYK Antibody (R1U80)
HW639014-01	Anti-RYK Polyclonal Antibody
TMAB-12440-01	Anti-RYK Antibody (6M535)
TMAB-12441-01	Anti-RYK Antibody (3G820)
STJ72806	Anti-Ryk (mouse) antibody
MBS9217037-01	RYK Antibody