Anti-SRGAP2 Antibody (C-term)

CAT: 0519-M05125-50ulSize: 50 µLDry Ice: NoHazardous: No

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CAT#:0519-M05125-50ulSize:50 µL

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Background

RAC1 GTPase activating protein (GAP) that binds and deforms membranes, and regulates actin dynamics to regulate cell migration and differentiation. Plays an important role in different aspects of neuronal morphogenesis and migration mainly during development of the cerebral cortex. This includes the biogenesis of neurites, where it is required for both axons and dendrites outgrowth, and the maturation of the dendritic spines. Also stimulates the branching of the leading process and negatively regulates neuron radial migration in the cerebral cortex. Its interaction and inhibition by SRGAP2C reduces the rate of spine maturation, alters dendritic spine morphology and density and indirectly increases neuronal migration. It may have implications for cognition, learning and memory. In non-neuronal cells, it may also play a role in cell migration by regulating the formation of lamellipodia and filopodia.

Description

Boster Bio Anti-SRGAP2 Antibody (C-term) (Catalog # M05125) . Tested in WB application (s) . This antibody reacts with Human, Mouse.

Synonyms

SLIT-ROBO Rho GTPase-activating protein 2, srGAP2, Formin-binding protein 2, Rho GTPase-activating protein 34, SRGAP2, ARHGAP34, FNBP2, KIAA0456, SRGAP2A

Gene Name

SRGAP2

UniProt

O75044

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

This SRGAP2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1040-1071amino acids from the C-terminal region of human SRGAP2.

Clonality

Polyclonal

Applications

Field of Research

Neuroscience, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Function

2081065327373832283332122255994427373832273738322081065321148482

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Observed Molecular Weight

120871 Da

Applications Notes

WB: 1:2000

Subcellular Location

Cell membrane. Cell projection, dendritic spine. Postsynaptic density {ECO:0000250|UniProtKB:Q91Z67}. Postsynaptic cell membrane {ECO:0000250|UniProtKB:Q91Z67}. Cell projection, lamellipodium. Cytoplasmic vesicle, phagosome {ECO:0000250|UniProtKB:Q91Z67}. Nucleus {ECO:0000250|UniProtKB:D4A208} Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q91Z67}. Note=Recruited to actin-rich phagosomes during phagocytosis (By similarity) . Translocates from nucleus to cytoplasm during development (By similarity) {ECO:0000250|UniProtKB:D4A208, ECO:0000250|UniProtKB:Q91Z67}

Isotype

Rabbit IgG

Contents

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

UniProtKB · O75044

SLIT-ROBO Rho GTPase-activating protein 2

SRGP2_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: O75044
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: SRGAP2
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: srGAP2
EC number: —
Processing: —
Secondary accessions: A2RUF3

Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Cellular component

Cell membraneCell projectionCytoplasmCytoplasmic vesicleMembraneNucleusPostsynaptic cell membraneSynapse

Coding sequence diversity

Chromosomal rearrangement

Domain

Coiled coilSH3 domain

Molecular function

GTPase activation

PTM

MethylationPhosphoprotein

Biological process

Neurogenesis

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