Ampicillin

• Description:

  Ampicillin is a broad-spectrum beta-lactam antibiotic against a variety of gram-positive and gram-negative bacteria.

• Product Name Alternative:

  D- (-) -α-Aminobenzylpenicillin

• UNSPSC:

  12352005

• Hazard Statement:

  H317, H334

• Target:

  Antibiotic; Bacterial

• Type:

  Reference compound

• Related Pathways:

  Anti-infection

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/Ampicillin.html

• Purity:

  99.92

• Solubility:

  H2O : 4.9 mg/mL (ultrasonic; warming; adjust pH to 9 with NaOH; heat to 60°C)

• Smiles:

  OC ([C@@H]1N (C2=O) [C@] ([C@@H]2NC ([C@@H] (C3=CC=CC=C3) N) =O) ([H]) SC1 (C) C) =O

• Molecular Formula:

  C16H19N3O4S

• Molecular Weight:

  349.40

• Precautions:

  H317, H334

• References & Citations:

  [1]Chopra SL, et al. Effect of Ampicillin on E. Coli of Swine Origin. Can J Comp Med Vet Sci. 1963 Sep;27 (9) :223-7.|[2]Lund B, et al. Ampicillin in portal and peripheral blood and bile after oral administration of ampicillin andpivampicillin. Eur J Clin Pharmacol. 1974;7 (2) :133-5.|[3]Lee KE, et al. The neuroprotective mechanism of ampicillin in a mouse model of transient forebrain ischemia. Korean J Physiol Pharmacol. 2016 Mar;20 (2) :185-92.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Launched

• Isoform:

  β-lactam

• Citation 01:

  ACS Infect Dis. 2023 Dec 8;9 (12) :2523-2537.|Adv Sci (Weinh) . 2025 Apr 28:e2409837.|AMB Express. 2024 Dec 24;14 (1) :141.|Anim Dis. 2021;1 (1) :26.|Antimicrob Agents Chemother. 2025 Aug 6;69 (8) :e0037925.|Aquaculture. 2021, 736248.|Biochem Biophys Res Commun. 2025 Jun 7:776:152161.|Biochem Pharmacol. 2024 Dec;230 (Pt 2) :116593.|Biomed Pharmacother. 2025 Jan:182:117756.|Biomed Res Int. 2018 Jul 2:2018:3579832.|bioRxiv. 2024 May 10.|bioRxiv. 2025 February 13.|bioRxiv. 2025 January 19.|Cancer Immunol Res. 2022 Dec 2;10 (12) :1542-1558.|Cell Metab. 2023 Nov 7;35 (11) :1961-1975.e6.|Cell Metab. 2025 Jan 7;37 (1) :87-103.e10.|Cell Rep Med. 2025 Oct 21;6 (10) :102410.|Chemosphere. 2023 Dec:344:140353.|Curr Res Food Sci. 2025 May 16:10:101084.|Diagn Microbiol Infect Dis. 2025 Nov 4;114 (2) :117181.|Emerg Microbes Infect. 2022 Dec;11 (1) :815-828.|Front Aging Neurosci. 2022 Jul 28;14:858130.|Genome Biol. 2023 Apr 30;24 (1) :98.|Gut Microbes. 2023 Dec;15 (2) :2249143.|Gut Microbes. 2023 Dec;15 (2) :2282790.|Heliyon. 2024 Jun 6;10 (11) :e32429.|Infect Genet Evol. 2025 Sep:133:105780.|iScience. 2023 Mar 11;26 (4) :106378.|iScience. 2023 Oct 7;26 (11) :108158.|iScience. 2025 May 13;28 (7) :112658.|iScience. 2025 May 27;28 (6) :112763.|J Agric Food Chem. 2024 Apr 10.|J Antimicrob Chemother. 2023 Apr 3;78 (4) :983-990.|J Antimicrob Chemother. 2024 Jul 13:dkae229.|J Antimicrob Chemother. 2024 Jul 20:dkae218.|J Cell Physiol. 2022 Mar;237 (3) :1845-1856.|J Nanobiotechnology. 2024 Nov 30;22 (1) :744.|J Neuroinflammation. 2025 Nov 4;22 (1) :259.|J Pharm Anal. 2023 Oct;13 (10) :1153-1167.|Life Metab. 2025 Oct 8.|Life Sci. 2020 Nov 15;261:118473.|Microbiol Spectr. 2022 Feb 23;10 (1) :e0099121.|Microorganisms. 2024 Mar 13;12 (3) :575.|Microorganisms. 2025 Apr 18;13 (4) :938.|Molecules. 2025 Mar 9;30 (6) :1224.|mSystems. 2023 Dec 21;8 (6) :e0102623.|Nat Commun. 2022 Mar 2;13 (1) :1116.|Naunyn Schmiedebergs Arch Pharmacol. 2025 Apr;398 (4) :3681-3695.|Neural Regen Res. 2024 Sep 1;19 (9) :2081-2088.|Nutrients. 2023 Oct 18;15 (20) :4427.|Pharmacol Res. 2024 May 21:205:107229.|Protoplasma. 2025 Nov 6.|Res Sq. 2024 Oct 02.|Res Sq. 2025 Aug 05.|Research Square Preprint. 2020 Jun.|Research Square Preprint. 2021 Feb.|SSRN. 2023 Sep 11.|Vet Microbiol. 2024 May:292:110046.|Vet Res Commun. 2024 Dec;48 (6) :3859-3872.|ACS Infect Dis. 2024 Aug 9;10 (8) :2961-2977.|ACS Omega. 2023 Mar 6;8 (10) :9652-9661.|Am J Chin Med. 2024 Aug 21:1-28.|Cancer Cell. 2025 Sep 25:S1535-6108 (25) 00394-0.|Cell Host Microbe. 2025 Jun 11;33 (6) :915-931.e9.|Cell Rep Med. 2023 Dec 19;4 (12) :101340.|Chin Med. 2025 Oct 3;20 (1) :155.|Emerg Microbes Infect. 2024 Dec;13 (1) :2321981.|Nano Today. 2025 Oct.|Nucleic Acids Res. 2022 Dec 9;50 (22) :12951-12968.|Sci Adv. 2023 Feb 17;9 (7) :eade4770.

• CAS Number:

  69-53-4