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Anti-MAP1LC3C Antibody

CAT: 0519-A08533Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0519-A08533Size:0.1 mg
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Background
Microtubule-associated proteins (MAPs) regulate microtubule stability and play critical roles in neuronal development and plasticity (1) . MAP1LC3C belongs to the MAP1 LC3 family of proteins that form mature complexes with MAP1A and MAP1B which are thought to be important in the formation and development of axons and dendrites (2) . MAP1LC3C is one of three isoforms of MAP1LC3, the mammalian homolog of yeast ATG8, an essential autophagy protein. These isoforms exhibit distinct expression patterns and MAP1LC3C, like MAP1LC3A but not MAP1LC3B, is post-translationally modified, suggesting the three isoforms may have different physiological functions (3) .
Description
Boster Bio Anti-MAP1LC3C Antibody (Catalog # A08533) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human.
Synonyms
LC3C, ATG8JAutophagy-related protein LC3 C
Gene Name
MAP1LC3C
UniProt
Q9BXW4
Host
Rabbit
Reactivity
Human
Cross Reactivity
MAP1LC3C antibody is human, mouse and rat reactive. Multiple isoforms MAP1LC3C are known to exist. MAP1LC3C antibody is predicted to not cross-react with MAP1LC3A or MAP1LC3B.
Immunogen
MAP1LC3C antibody was raised against an 18 amino acid peptide near the carboxy terminus of human MAP1LC3C. The immunogen is located within the last 50 amino acids of MAP1LC3C.
Clonality
Polyclonal
Tissue Specificity
Most abundant in placenta, lung and ovary.
Applications
ELISA, WB, IHC-P, IF
Field of Research
Autophagy
Purification
MAP1LC3C antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL
Form
Liquid
Function
Ubiquitin-like modifier that plays a crucial role in antibacterial autophagy (xenophagy) through the selective binding of CALCOCO2. Recruits all ATG8 family members to infecting bacteria such as S.Typhimurium (PubMed:23022382) . May also play a role in aggrephagy, the macroautophagic degradation of ubiquitinated and aggregated proteins (PubMed:28404643) .
Storage Conditions
MAP1LC3C antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
Observed Molecular Weight
16852 MW
Gene Name Synonym
Microtubule-associated protein 1 light chain 3 gamma
Subcellular Location
Cytoplasm, cytoskeleton
Protein Name
Microtubule-associated protein 1 light chain 3 gamma
Isotype
IgG
Contents
MAP1LC3C antibody is supplied in PBS containing 0.02% sodium azide.

UniProtKB · Q9BXW4

Microtubule-associated protein 1 light chain 3 gamma

MLP3C_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q9BXW4
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
MAP1LC3C
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
A0PJY8, A2RUP0
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Biological process

AutophagyUbl conjugation pathway

Cellular component

CytoplasmCytoplasmic vesicleCytoskeletonMembraneMicrotubule

PTM

LipoproteinPhosphoprotein

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