Products for Research Use Only
RegisterLogin

Anti-TLK2 Antibody

CAT: 0519-A06645-2Size: 100 µLDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0519-A06645-2Size:100 µL
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
Tousled-like kinases (TLKs) are a family of serine/threonine kinases located in the nucleus that promote S-phase chromatin assembly and mitotic chromosome segregation. There are two genes in the TLK family-TLK1 and TLK2 (PMID: 14561777) . Mutation in TLK2 are associated with an elevated risk of breast cancer (PMID: 27489360) . Tousled-like kinase 2 (TLK2) is a key factor in glioblastoma that modulates SRC signaling, thereby driving tumor malignancy. TLK2 is commonly upregulated in glioblastoma, and such upregulation was associated with poor patient outcomes. TLK2 overexpression induced cell growth, migration, invasion, and epithelialmesenchymal transition, and cell cycle arrest, while TLK2 knockdown had the opposite effect (PMID: 30207834) . It can detect 3 isoforms of 88, 85 and 82 kDa.
Description
Boster Bio Anti-TLK2 Antibody catalog # A06645-2. Tested in WB, IHC, ICC/IF, ELISA applications. This antibody reacts with Human, Mouse, Rat.
Gene Name
TLK2
UniProt
Q86UE8
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
E.coli-derived human TLK2 recombinant protein (Position: P514-S828) .
Clonality
Polyclonal
Applications
WB, IHC, ICC/IF, ELISA
Purification
Immunogen affinity purified.
Concentration
500 μg/mL
Form
Liquid
Storage Conditions
12 months from date of receipt, -20°C as supplied. 6 months 2 to 8°C after reconstitution. Avoid repeated freezing and thawing.
Contents
500 μg/mL antibody with PBS,0.02% NaN3, 1 mg BSA and 50% glycerol.

UniProtKB · Q86UE8

Serine/threonine-protein kinase tousled-like 2

TLK2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q86UE8
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
TLK2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
2.7.11.1
Processing
—
Secondary accessions
D3DU07, Q9UKI7, Q9Y4F7
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Ligand

ATP-bindingNucleotide-binding

Biological process

Cell cycleDNA damage

Molecular function

Chromatin regulatorKinaseSerine/threonine-protein kinaseTransferase

Domain

Coiled coil

Cellular component

CytoplasmCytoskeletonNucleus

Disease

Disease variantIntellectual disability

PTM

Phosphoprotein

Related Products

CatalogName
M06645-1Anti-TLK2 Mouse Monoclonal Antibody [Clone ID: OTI2G1]
M06645Anti-TLK2 Mouse Monoclonal Antibody [Clone ID: OTI2D10]
M06645-2Anti-TLK2 Mouse Monoclonal Antibody [Clone ID: OTI2H2]
PROTQ86UE8TLK2 (NM_006852) Human Recombinant Protein
LS011011TLK2 (NM_006852) Human Over-expression Lysate
LS011011-100ugTLK2 (NM_006852) Human Over-expression Lysate
LS011011-20ugTLK2 (NM_006852) Human Over-expression Lysate
A05635-1Anti-TLK1 Antibody
A05635S743Anti-TLK1 (phospho-S743) Antibody
A09597-2Anti-ANT4/SLC25A31 Antibody

Alternative Products

CatalogName
MBS8292334-01Anti-TLK2 Antibody
SL7925R-01Rabbit Anti-TLK2 antibody
70R-9600TLK2 antibody

Popular Products