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Anti-PPP4C Antibody

CAT: 0519-A06390Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0519-A06390Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Boster Bio Anti-PPP4C Antibody catalog # A06390. Tested in WB, IHC, IP applications. This antibody reacts with Human, Mouse, Rat.
Synonyms
Serine/threonine-protein phosphatase 4 catalytic subunit; PP4C; Pp4;3.1.3.16
Gene Name
PPP4C
UniProt
P60510
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein of human PPP4C (NP_002711.1) .
Clonality
Polyclonal
Applications
WB, IHC, IP
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Concentration
1 mg/mL
Form
Liquid
Function
Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF) -alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C- PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-140 (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase (By similarity) . In response to DNA damage, catalyzes RPA2 dephosphorylation, an essential step for DNA repair since it allows the efficient RPA2-mediated recruitment of RAD51 to chromatin.
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight
35080 MW
Gene Name Synonym
Serine/threonine-protein phosphatase 4 catalytic subunit
Subcellular Location
Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Protein Name
Serine/threonine-protein phosphatase 4 catalytic subunit
Contents
Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

UniProtKB · P60510

Serine/threonine-protein phosphatase 4 catalytic subunit

PP4C_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P60510
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
PPP4C
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
PP4C, Pp4
EC number
3.1.3.16
Processing
—
Secondary accessions
P33172
Protein keywords

PTM

AcetylationMethylationUbl conjugation

Cellular component

CytoplasmCytoskeletonNucleus

Molecular function

HydrolaseProtein phosphatase

Ligand

ManganeseMetal-binding

Technical term

Proteomics identificationReference proteome

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