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Anti-DMAP1 Antibody

CAT: 0519-A03688Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0519-A03688Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Boster Bio Anti-DMAP1 Antibody catalog # A03688. Tested in WB, IHC applications. This antibody reacts with Human, Mouse, Rat.
Synonyms
DNA methyltransferase 1-associated protein 1; DNMAP1; DNMT1-associated protein 1; DMAP1; KIAA1425
Gene Name
DMAP1
UniProt
Q9NPF5
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein of human DMAP1 (NP_061973.1) .
Clonality
Polyclonal
Applications
WB, IHC
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Concentration
1 mg/mL
Form
Liquid
Function
Involved in transcription repression and activation. Its interaction with HDAC2 may provide a mechanism for histone deacetylation in heterochromatin following replication of DNA at late firing origins. Can also repress transcription independently of histone deacetylase activity. May specifically potentiate DAXX- mediated repression of glucocorticoid receptor-dependent transcription. Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Participates in the nuclear localization of URI1 and increases its transcriptional corepressor activity.
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight
52993 MW
Gene Name Synonym
DNA methyltransferase 1-associated protein 1
Subcellular Location
Nucleus. Cytoplasm. Targeted to replication foci throughout S phase by DNMT1.
Protein Name
DNA methyltransferase 1-associated protein 1
Contents
Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

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