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Anti-DFF45 DFFA Antibody

CAT: 0519-A03671Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0519-A03671Size:0.1 mg
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Background
Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. These death signals finally cause the degradation of chromosomal DNA by activated DNase. A human 45 kDa DNA fragmentation factor (DFF45) was identified recently which was cleaved by caspase-3 during apoptosis. Mouse homologue of human DFF45 was identified as a DNase inhibitor designated ICAD. Upon cleavage of DFF45/ICAD, a caspase activated deoxyribonuclease (DFF40/CAD) is released and activated and eventually causes the degradation of DNA in the nuclei. Therefore, the cleavage of DFF45/ICAD, which causes DFF40/CAD activation and DNA degradation, is the hallmark of apoptotic cell death.
Description
Boster Bio Anti-DFF45 DFFA Antibody (Catalog # A03671) . Tested in ELISA, WB, ICC, IF applications. This antibody reacts with Human.
Synonyms
DFF1, ICAD, DFF-45, DFF1, DFF45, H13, DNA fragmentation factor subunit alpha, DNA fragmentation factor 45 kDa subunit
Gene Name
DFFA
UniProt
O00273
Host
Rabbit
Reactivity
Human
Immunogen
DFF45 antibody was raised against a 19 amino acid peptide near the carboxy terminus of human DFF45. The immunogen is located within the last 50 amino acids of DFF45.
Clonality
Polyclonal
Tissue Specificity
Isoform 1 is found in both brain and placenta.
Applications
ELISA, WB, ICC, IF
Field of Research
Apoptosis
Purification
DFF45 Antibody is Antibody is DEAE purified.
Concentration
1 mg/mL
Form
Liquid
Function
Inhibitor of the caspase-activated DNase (DFF40) .
Storage Conditions
DFF45 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Observed Molecular Weight
36522 MW
Gene Name Synonym
DNA fragmentation factor, 45kDa, alpha polypeptide
Subcellular Location
Cytoplasm.
Protein Name
DNA fragmentation factor, 45kDa, alpha polypeptide
Isotype
IgG
Contents
DFF45 Antibody is supplied in PBS containing 0.02% sodium azide.

UniProtKB · O00273

DNA fragmentation factor subunit alpha

DFFA_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O00273
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
DFFA
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
Q5T6G5, Q5T6G6, Q96I97, Q9Y6C6
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationPhosphoprotein

Coding sequence diversity

Alternative splicing

Biological process

Apoptosis

Cellular component

Cytoplasm

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