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Anti-EIF3A Antibody

CAT: 0519-A02339Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0519-A02339Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Boster Bio Anti-EIF3A Antibody catalog # A02339. Tested in WB, ICC/IF applications. This antibody reacts with Human, Mouse.
Synonyms
Eukaryotic translation initiation factor 3 subunit A
Gene Name
EIF3A
UniProt
Q14152
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Recombinant fusion protein of human EIF3A (NP_003741.1) .
Clonality
Polyclonal
Applications
WB, ICC, IF
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Concentration
1 mg/mL
Form
Liquid
Function
RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773) . The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC) . The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632, PubMed:11169732) . The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773, PubMed:27462815) .
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight
166569 MW
Gene Name Synonym
Eukaryotic translation initiation factor 3 subunit A
Subcellular Location
Cytoplasm
Protein Name
Eukaryotic translation initiation factor 3 subunit A
Contents
Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

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