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Anti-TRIM63 Antibody

CAT: 0519-A02016Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0519-A02016Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Boster Bio Anti-TRIM63 Antibody catalog # A02016. Tested in WB, IHC, ICC/IF applications. This antibody reacts with Human, Mouse, Rat.
Synonyms
E3 ubiquitin-protein ligase TRIM63;2.3.2.27; Iris RING finger protein; Muscle-specific RING finger protein 1; MuRF-1; MuRF1; RING finger protein 28; RING-type E3 ubiquitin transferase TRIM63 ; Striated muscle RING zinc finger protein; Tripartite motif-containing protein 63; TRIM63; IRF, MURF1, RNF28, SMRZ
Gene Name
TRIM63
UniProt
Q969Q1
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 253-353 of human TRIM63 (NP_115977.2) .
Clonality
Polyclonal
Tissue Specificity
Muscle specific. Selectively expressed in heart and skeletal muscle. Also expressed in the iris.
Applications
WB, IHC, ICC, IF
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Concentration
1 mg/mL
Form
Liquid
Function
E3 ubiquitin ligase. Mediates the ubiquitination and subsequent proteasomal degradation of CKM, GMEB1 and HIBADH. Regulates the proteasomal degradation of muscle proteins under amino acid starvation, where muscle protein is catabolized to provide other organs with amino acids. Inhibits de novo skeletal muscle protein synthesis under amino acid starvation. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striated muscle atrophy and hypertrophy by regulating an anti- hypertrophic PKC-mediated signaling pathway. May regulate the organization of myofibrils through TTN in muscle cells.
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight
40248 MW
Gene Name Synonym
E3 ubiquitin-protein ligase TRIM63
Subcellular Location
Cytoplasm. Nucleus . Cytoplasm, myofibril, sarcomere, M line. Cytoplasm, myofibril, sarcomere, Z line. Colocalizes with TNNI3 in myocytes (By similarity) . Localizes to the M- and Z-lines in skeletal muscle. .
Protein Name
E3 ubiquitin-protein ligase TRIM63
Contents
Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

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