Anti-COT MAP3K8 Antibody

• Description:

  Boster Bio Anti-COT MAP3K8 Antibody catalog # A01696. Tested in WB, IHC, IF, ELISA applications. This antibody reacts with Human, Mouse, Rat.

• Synonyms:

  Mitogen-activated protein kinase kinase kinase 8;2.7.11.25; Cancer Osaka thyroid oncogene; Proto-oncogene c-Cot; Serine/threonine-protein kinase cot; Tumor progression locus 2; TPL-2; MAP3K8; COT, ESTF

• Gene Name:

  MAP3K8

• UniProt:

  P41279

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  The antiserum was produced against synthesized peptide derived from human COT. AA range:256-305

• Tissue Specificity:

  Expressed in several normal tissues and human tumor-derived cell lines.

• Applications:

  WB, IHC, IF, ELISA

• Purification:

  Immunogen affinity purified

• Concentration:

  1 mg/mL

• Form:

  Liquid

• Function:

  Required for lipopolysaccharide (LPS) -induced, TLR4- mediated activation of the MAPK/ERK pathway in macrophages, thus being critical for production of the proinflammatory cytokine TNF- alpha (TNF) during immune responses. Involved in the regulation of T-helper cell differentiation and IFNG expression in T-cells. Involved in mediating host resistance to bacterial infection through negative regulation of type I interferon (IFN) production. In vitro, activates MAPK/ERK pathway in response to IL1 in an IRAK1-independent manner, leading to up-regulation of IL8 and CCL4. Transduces CD40 and TNFRSF1A signals that activate ERK in B- cells and macrophages, and thus may play a role in the regulation of immunoglobulin production. May also play a role in the transduction of TNF signals that activate JNK and NF-kappa-B in some cell types. In adipocytes, activates MAPK/ERK pathway in an IKBKB-dependent manner in response to IL1B and TNF, but not insulin, leading to induction of lipolysis. Plays a role in the cell cycle. Isoform 1 shows some transforming activity, although it is much weaker than that of the activated oncogenic variant. .

• Storage Conditions:

  Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

• Observed Molecular Weight:

  52925 MW

• Gene Name Synonym:

  Mitogen-activated protein kinase kinase kinase 8

• Subcellular Location:

  Cytoplasm .

• Isotype:

  IgG

• Contents:

  Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.