Anti-SRC Antibody (N-term)

CAT: 0519-A00107-80ulSize: 80 µLDry Ice: NoHazardous: No

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CAT#:0519-A00107-80ulSize:80 µL

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Background

The gene for SRC is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. SRC, the protein encoded by this gene, is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in SRC could be involved in the malignant progression of colon cancer.

Description

Boster Bio Anti-SRC Antibody (N-term) (Catalog # A00107) . Tested in WB, IF, IHC-P application (s) . This antibody reacts with Human, Mouse.

Synonyms

Proto-oncogene tyrosine-protein kinase Src, Proto-oncogene c-Src, pp60c-src, p60-Src, SRC, SRC1

Gene Name

SRC

UniProt

P12931

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

This SRC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human SRC.

Clonality

Polyclonal

Tissue Specificity

Expressed ubiquitously. Platelets, neurons and osteoclasts express 5-fold to 200-fold higher levels than most other tissues [Isoform 2]: Expressed in brain.

Applications

WB, IF, IHC-P

Field of Research

Cancer, Signal Transduction, Host-Virus Interaction, Immunology, Chemokine signaling, Mitochondria

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Function

21411625113897301858695378535078755529145859631261591016186108201008352130975019419966145859632271072320525694193075962573115935927303

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Observed Molecular Weight

59835 Da

Subcellular Location

Cell membrane; Lipid-anchor. Mitochondrion inner membrane. Nucleus. Cytoplasm, cytoskeleton. Cytoplasm, perinuclear region. Cell junction, focal adhesion. Note=Localizes to focal adhesion sites following integrin engagement (PubMed:22801373) . Localization to focal adhesion sites requires myristoylation and the SH3 domain (PubMed:7525268) . Colocalizes with PDLIM4 at the perinuclear region, but not at focal adhesions (PubMed:19307596)

Isotype

Rabbit IgG

Contents

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

UniProtKB · P12931

Proto-oncogene tyrosine-protein kinase Src

SRC_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: P12931
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: SRC
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: 2.7.10.2
Processing: —
Secondary accessions: E1P5V4, Q76P87, Q86VB9, Q9H5A8

Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Ligand

ATP-bindingNucleotide-binding

Biological process

Cell adhesionCell cycleHost-virus interactionImmunity

Cellular component

Cell junctionCell membraneCytoplasmCytoskeletonMembraneMitochondrionMitochondrion inner membraneNucleus

Disease

Disease variantProto-oncogene

Molecular function

KinaseTransferaseTyrosine-protein kinase

PTM

LipoproteinMyristatePhosphoproteinUbl conjugation

Domain

SH2 domainSH3 domain

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Alternative Products

Catalog	Name
MBS9202105-01	SRC Antibody (N-term)
APR04447G-01	SRC Antibody (N-term) [APR04447G]
APR06970G	Polyclonal SRC Antibody (N-term)
APR32486G-01	SRC Antibody (N-term) [APR32486G]
GTR18784616-01	Mouse Src Antibody (N-term)
E28PB4419	SRC Rabbit Polyclonal Antibody (N-term)
AP14476PU-N	SRC (N-term) Rabbit Polyclonal Antibody
MBS9224414-01	SRC Antibody(N-term) Blocking peptide
MBS9227195-01	SRC Antibody (N-term) Blocking Peptide
AP22686PU-N	SRC (N-term) rabbit polyclonal antibody, Purified