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Anti-DOCK8 Antibody Picoband®

CAT: 0519-A01771-1Size: 100 µg/VialDry Ice: NoHazardous: No
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CAT#:0519-A01771-1Size:100 µg/Vial
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes a member of the DOCK180 family of guanine nucleotide exchange factors. Guanine nucleotide exchange factors interact with Rho GTPases and are components of intracellular signaling networks. Mutations in this gene result in the autosomal recessive form of the hyper-IgE syndrome. Alternatively spliced transcript variants encoding different isoforms have been described.
Description
Boster Bio Anti-DOCK8 Antibody Picoband® catalog # A01771-1. Tested in WB, IHC, Flow Cytometry, ELISA applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Synonyms
DOCK8; Dedicator of cytokinesis protein 8
Gene Name
DOCK8
Gene ID
81704
UniProt
Q8NF50
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins
Immunogen
E.coli-derived human DOCK8 recombinant protein (Position: M1-S2099) . Human DOCK8 shares 91.8% amino acid (aa) sequence identity with mouse DOCK8.
Clonality
Polyclonal
Applications
WB, IHC, Flow Cytometry, ELISA
Purification
Immunogen affinity purified.
Concentration
Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.
Form
Lyophilized
Reconstitution
Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.
References & Citations
1. Griggs, B. L., Ladd, S., Saul, R. A., DuPont, B. R., Srivastava, A. K. Dedicator of cytokinesis 8 is disrupted in two patients with mental retardation and developmental disabilities. Genomics 91: 195-202, 2008. 2. MacDermot, K. D., Hulten, M. Female with hypohidrotic ectodermal dysplasia and de novo (X;9) translocation: clinical documentation of the AnLy cell line case. Hum. Genet. 84: 577-579, 1990. 3. Pillay, B. A., Fusaro, M., Gray, P. E., Statham, A. L., Burnett, L., Bezrodnik, L., Kane, A., Tong, W., Abdo, C., Winter, S., Chevalier, S., Levy, R., and 18 others. Somatic reversion of pathogenic DOCK8 variants alters lymphocyte differentiation and function to effectively cure DOCK8 deficiency. J. Clin. Invest. 131: e142434, 2021.
Storage Conditions
At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
Calculated Molecular Weight
239 kDa
Observed Molecular Weight
230 kDa
Applications Notes
6
Gene Name Synonym
Dedicator of cytokinesis 8
Protein Name
Dedicator of cytokinesis protein 8
Isotype
Rabbit IgG
Contents
Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

UniProtKB · Q8NF50

Dedicator of cytokinesis protein 8

DOCK8_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q8NF50
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
DOCK8
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
A2A350, A2BDF2, A4FU78, B7ZLP0, E9PH09, Q3MV16, Q5JPJ1, Q8TEP1, Q8WUY2, Q9BYJ5, Q9H1Q2, Q9H1Q3, Q9H308, Q9H7P2
Protein keywords

Coding sequence diversity

Alternative splicingChromosomal rearrangement

Cellular component

Cell membraneCell projectionCytoplasmMembrane

Disease

Disease variantIntellectual disability

Molecular function

Guanine-nucleotide releasing factor

PTM

Phosphoprotein

Technical term

Proteomics identificationReference proteome

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