Anti-IL4R Antibody

CAT: 0519-A00807-2Size: 100 µg/VialDry Ice: NoHazardous: No

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CAT#:0519-A00807-2Size:100 µg/Vial

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Background

IL4R (INTERLEUKIN 4 RECEPTOR) is a human gene that encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE antibody production in B cells. The IL4R gene is localized to 16p12.1-p11.2 by in situ hybridization and Southern blot analysis of DNA from a panel of mouse-human somatic cell lines. IL4 plays a major role in immunoglobulin E (IgE) production. Its signal is conferred to effector cells through binding to the alpha chain of the IL4 receptor. IL4 interacts with IL4R with high affinity, leading to dimerization with either the common gamma chain, a component of receptors for a number of cytokines, to create a type I receptor, or with IL13RA1 to form a type II receptor.The IL4R gene contains 12 exons and IL4R is a complex of at least 2 components, one of which is a novel affinity converting subunit that is critical for cellular signal transduction. See also IL13RA1 and IL13RA2.

Description

Boster Bio Anti-IL4R Antibody Picoband® catalog # A00807-2. Tested in ELISA, Flow Cytometry, IHC applications. This antibody reacts with Mouse, Rat.

Synonyms

Oncostatin-M; OSM; Osm

Gene Name

Il4r

Gene ID

25084

UniProt

Q63257

Host

Rabbit

Reactivity

Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived rat IL4R recombinant protein (Position: I26-E719) .

Clonality

Polyclonal

Tissue Specificity

Widely expressed. Expressed at higher levels in liver, skin and spleen.

Applications

IHC, Flow Cytometry, ELISA

Field of Research

Nuclear Signaling Pathways, Signal Transduction, Signaling Pathway

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500μg/ml.

Function

Growth regulator. Inhibits the proliferation of a number of tumor cell lines. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells (By similarity) . Uses only type II OSM receptor (heterodimers composed of OSMR and IL6ST) . Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration.

References & Citations

1. Bergin, A.-M., Balder, B., Kishore, S., Sward, K., Hahn-Zoric, M., Lowhagen, O., Hanson, L. A., Padyukov, L. Common variations in the IL4R gene affect splicing and influence natural expression of the soluble isoform. Hum. Mutat. 27: 990-998, 2006. 2. Blaeser, F., Bryce, P. J., Ho, N., Raman, V., Dedeoglu, F., Donaldson, D. D., Geha, R. S., Oettgen, H. C., Chatila, T. A. Targeted inactivation of the IL-4 receptor alpha chain I4R motif promotes allergic airway inflammation. J. Exp. Med. 198: 1189-1200, 2003. 3. Ikizawa, K; Yanagihara Y (Feb. 2000) . Possible involvement of Shc in IL-4-induced germline epsilon transcription in a human B cell line. Biochem. Biophys. Res.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

180 kDa

Applications Notes

Gene Name Synonym

Oncostatin M

Subcellular Location

Secreted.

Isotype

Rabbit IgG

Contents

Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.005mg NaN3.

UniProtKB · Q63257

Interleukin-4 receptor subunit alpha

IL4RA_RAT · Rattus norvegicus

View on UniProt ↗

Primary accession: Q63257
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: Il4r
Protein existence: 2: Evidence at transcript level
Organism: Rattus norvegicus (Rat)
Taxonomy ID: 10116
Alternative names: IL-4 receptor subunit alpha, IL-4R subunit alpha, IL-4R-alpha, IL-4RA
EC number: —
Processing: Precursor
Secondary accessions: Q9R1W8, Q9WTM8

Protein keywords

Coding sequence diversity

Alternative splicing

Cellular component

Cell membraneMembraneSecreted

PTM

Disulfide bondGlycoproteinPhosphoprotein

Molecular function

Receptor

Technical term

Reference proteome

Domain

SignalTransmembraneTransmembrane helix

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