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Caspase-1 Polyclonal Antibody

CAT: 0749-ABP0180Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0749-ABP0180Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
CASP1 (caspase 1) encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. CASP1 was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. CASP1 has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms.
Description
Rabbit Anti-Caspase-1 Polyclonal Antibody
Product Name Alternative
Caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)
Gene ID
834
Accession Number
P29466
Reactivity
Human, Mouse, Rat
Immunogen
Synthesized peptide derived from Caspase-1 at AA range: internal
Clonality
Polyclonal
Tag
Caspase-1
Applications
IF, WB, IHC, ELISA
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Molecular Weight
45kD,35kD, cleaced isform p10 :10kD
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Notes
Caspase-1 Polyclonal Antibody detects endogenous levels of Caspase-1.
Formulation
Liquid solution
Buffer pH
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Applications Notes
Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IF 1:50-200; WB 1:500-2000; IHC 1:50-300; ELISA 1:10000-20000
Other Product Names
Caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)
Tested Applications
WB, IHC, IF, IP, ELISA
Host or Source
Rabbit
Accession Number URL
http://www.uniprot.org/uniprot/P29466
Isotype
Rabbit IgG

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