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INH14

CAT: 0804-HY-114454-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-114454-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
INH14 is a cell permeable inhibitor of IKKα/IKKβ, with IC50s of 8.97 and 3.59 μM, respectively. INH14 inhibits the IKKα/β-dependent TLR inflammatory response. INH14 also inhibits downstream of TAK1/TAB1 and NF-kB pathways. Anti-inflammatory and anti-cancer activity[1].
CAS Number
200134-22-1
Product Name Alternative
2-APV; DL-2-Amino-5-phosphonovaleric acid, D-APV; D-2-Amino-5-phosphonovaleric acid
UNSPSC
12352005
Hazard Statement
H302, H319, H372, H410
Target
IKK
Type
Reference compound
Related Pathways
NF-κB
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/INH14.html
Concentration
10mM
Purity
98.0
Solubility
DMSO : ≥ 125 mg/mL
Smiles
O=C(NC1=CC=CC=C1)NC2=CC=C(CC)C=C2
Molecular Formula
C15H16N2O
Molecular Weight
240.30
Precautions
H302, H319, H372, H410
References & Citations
[1]Drexel M, et al. INH14, a Small-Molecule Urea Derivative, Inhibits the IKKα/β-Dependent TLR Inflammatory Response. Chembiochem. 2019 Mar 1;20 (5) :710-717.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IKK-α; IKK-β

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