Ivacaftor-d9

Ivacaftor-d9

• Product Name Alternative: VX-770-d9
• CAS Number: 1413431-07-8
• UNSPSC Description: Ivacaftor-d9 is a potent CFTR modulator and exhibits an EC50 value of 255 nM for CFTR potentiation in G551D/F508del HBE Cells. Ivacaftor-D9 acts as an orally active and improved deuterated Ivacaftor analog for cystic fibrosis research[1].
• Target Antigen: CFTR
• Type: Isotope-Labeled Compounds
• Related Pathways: Membrane Transporter/Ion Channel
• Field of Research: Cancer
• Purity: 99.83
• Solubility: DMSO : 100 mg/mL (ultrasonic)
• Smiles: CC(C)(C1=CC(C(C([2H])([2H])[2H])(C([2H])([2H])[2H])C([2H])([2H])[2H])=C(C=C1NC(C2=CNC(C=CC=C3)=C3C2=O)=O)O)C
• Molecular Weight: 401.55
• References & Citations: [1]Scott L Harbeson, et al. Altering Metabolic Profiles of Drugs by Precision Deuteration 2: Discovery of a Deuterated Analog of Ivacaftor with Differentiated Pharmacokinetics for Clinical Development. J Pharmacol Exp Ther. 2017 Aug;362(2):359-367.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: Launched