Products for Research Use Only
RegisterLogin

O-Desmethylcarvedilol

CAT: 0804-HY-Z7733Size: 1 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-Z7733Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
O-Desmethylcarvedilol (Desmethylcarvedilol) is an active metabolite of the non-selective β-adrenergic receptor (β-AR) antagonist Carvedilol. O-Desmethylcarvedilol inhibits store-overload-induced calcium release in HEK293 cells expressing the ryanodine receptor 2 (RyR2) R4496C (RyR2R4496C) mutation (IC50 = 7.62 µM). O-Desmethylcarvedilol reduces increases in heart rate and prevents decreases in diastolic blood pressure induced by Isoproterenol (HY-B0468) in conscious rabbits (ED50s = 32 and 5 µg/kg, respectively)[2].
CAS Number
72956-44-6
Product Name Alternative
Desmethylcarvedilol; BM-14242
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Calcium Channel
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Field of Research
Metabolic Disease
Purity
97.4
Smiles
OC1=C(OCCNCC(COC2=CC=CC3=C2C4=C(C=CC=C4)N3)O)C=CC=C1
Molecular Formula
C23H24N2O4
Molecular Weight
392.45
Precautions
H302, H315, H319, H335
References & Citations
[1]Chris D Smith, et al. Novel carvedilol analogues that suppress store-overload-induced Ca2+ release. J Med Chem. 2013 Nov 14;56 (21) :8626-55.|[2]K Strein, et al. Pharmacological profile of carvedilol, a compound with β-blocking and vasodilating properties. J Cardiovasc Pharmacol. 1987:10 Suppl 11:S33-41.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-W923645-01Fluorescein O, O′-diacrylate
HY-137960-01O, O-Dimethyl-cannabigerol
HY-176364AZD9496-O-C3-O-C3-O-C-acid
HY-1547293’-O-Methyl-2’-O-acetyl-5’-O-benzoyluridine
HY-W778150-01O, O-Dimethyl Phosphorothionate-d6 (ammonium)
HY-W778144-01O, O-Diethyl Thiophosphate-13C4 (ammonium)
HY-N10757Petunidin-3-O- (6-O-p-coumaryl) -5-O-diglucoside
HY-N9529-01Kaempferol 3-O- (2′′-O-α-rhamnosyl-6′′-O-malonyl-β-glucoside)
HY-N11497-013-O-Feruloyl-6′-O- (4-O-β-D-glucopyranosylferuloyl) sucrose
HY-N880810-O-Coumaroyl-10-O-deacetylasperuloside

Alternative Products

CatalogName
OR1075408O-Desmethylcarvedilol
MBS6025024-01(R)-(+)-O-Desmethylcarvedilol
D3220-86QS- (-) -O-Desmethylcarvedilol
D3220-86P(R) - (+) -O-Desmethylcarvedilol
MBS6038647-01(S)-(-)-O-Desmethylcarvedilol
B1077-96VS- (-) -O-Benzyl-O-desmethylcarvedilol
MBS6108169-01(S)-(-)-O-Benzyl-O-desmethylcarvedilol
sc-220038(S) - (-) -O-Benzyl-O-desmethylcarvedilol
MBS6089296-012'-O-Benzyloxy-2-O-desmethylcarvedilol
B1078-02W2’-O-Benzyloxy-2-O-desmethylcarvedilol

Popular Products