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N-Methylparoxetine

CAT: 0804-HY-Z3832-01Size: 250 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-Z3832-01Size:250 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
N-Methylparoxetine is a derivative of Paroxetine that induces Apoptosis NSCLC cells by activating mitogen-activated protein kinase (MAPK) . N-Methylparoxetine has antitumor activity[1].
CAS Number
110429-36-2
UNSPSC
12352005
Hazard Statement
H301, H410
Target
Apoptosis; Autophagy; p38 MAPK
Related Pathways
Apoptosis; Autophagy; MAPK/ERK Pathway
Applications
COVID-19-immunoregulation
Field of Research
Cancer
Purity
99.97
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CN(C1)CC[C@@H](C2=CC=C(C=C2)F)[C@@H]1COC3=CC=C(OCO4)C4=C3
Molecular Formula
C20H22FNO3
Molecular Weight
343.39
Precautions
H301, H410
References & Citations
[1]Wang K, et al. N-Methylparoxetine Blocked Autophagic Flux and Induced Apoptosis by Activating ROS-MAPK Pathway in Non-Small Cell Lung Cancer Cells. Int J Mol Sci. 2019 Jul 11;20 (14) :3415.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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