Isobutyramide

• Description :

  Aldehyde Dehydrogenase Isobutyramide is an orally active liver alcohol dehydrogenase (LADH2) inhibitor. Isobutyramide inhibits ethanol metabolism and enhances differentiation-related gene expression, inducing cell cycle arrest and significantly reducing the growth rate of prostate cancer cells (LNCaP) . Isobutyramide is promising for research of advanced prostate cancer[1][2].

• UNSPSC :

  12352211

• Hazard Statement :

  H302

• Target :

  Drug Metabolite

• Related Pathways :

  Metabolic Enzyme/Protease

• Field of Research :

  Cancer

• Purity :

  99.66

• Smiles :

  O=C(N)C(C)C

• Molecular Formula :

  C4H9NO

• Molecular Weight :

  87.12

• Precautions :

  H302

• References & Citations :

  [1]Chadha VK, et al. Inhibition by carboxamides and sulfoxides of liver alcohol dehydrogenase and ethanol metabolism. J Med Chem. 1983 Jun;26 (6) :916-22.|[2]Gleave ME, et al. Butyrate analogue, isobutyramide, inhibits tumor growth and time to androgen-independent progression in the human prostate LNCaP tumor model. J Cell Biochem. 1998 Jun 1;69 (3) :271-81.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  Store at room temperature 3 years

• Scientific Category :

  Reference compound2

• Clinical Information :

  No Development Reported

• CAS Number :

  [563-83-7]