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Flindersine

CAT: 0804-HY-W984782Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-W984782Size:1 Each
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Description
Flindersine is an antidiabetic and antioxidant agent. Flindersine can result in a decline of blood glucose levels in rats. Flindersine also reduces the body weight gain, plasma insulin concentration, urea, creatinine, total cholesterol, triglycerides and free fatty acids levels in vivo. Flindersine enhances the phophotylation of GLUT4, AMPK, and PPARγ in adipose tissues and skeletal muscles[1].
CAS Number
523-64-8
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
AMPK; GLUT; PPAR; Reactive Oxygen Species (ROS)
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; Immunology/Inflammation; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; NF-κB; PI3K/Akt/mTOR; Vitamin D Related/Nuclear Receptor
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Smiles
O=C1NC2=C(C3=C1C=CC(C)(C)O3)C=CC=C2
Molecular Formula
C14H13NO2
Molecular Weight
227.26
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Irudayaraj, S. S., et al., (2022) . Antidiabetic with antilipidemic and antioxidant effects of flindersine by enhanced glucose uptake through GLUT4 translocation and PPARγ agonism in type 2 diabetic rats. Journal of ethnopharmacology, 285, 114883.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported

Chemical Information

Flindersine

Flindersine is an organic heterotricyclic compound, an organonitrogen heterocyclic compound and an oxacycle.

CAS Number523-64-8
PubChem CID68230
IUPAC Name2,2-dimethyl-6H-pyrano[3,2-c]quinolin-5-one
Molecular FormulaC14H13NO2
Molecular Weight227.26
XLogP2
Topological Polar Surface Area38.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count0
Heavy Atom Count17
Formal Charge0
Complexity420
SMILES
CC1(C=CC2=C(O1)C3=CC=CC=C3NC2=O)C
InChI
InChI=1S/C14H13NO2/c1-14(2)8-7-10-12(17-14)9-5-3-4-6-11(9)15-13(10)16/h3-8H,1-2H3,(H,15,16)
InChIKey
PXNMNABLQWUMCX-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Flindersine
CAS: 523-64-8
CID: 68230
Formula: C14H13NO2
MW: 227.26
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight227.26
XLogP32
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count0
Exact Mass227.094628657
Monoisotopic Mass227.094628657
Topological Polar Surface Area38.3 Ų
Heavy Atom Count17
Formal Charge0
Complexity420
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
GTR19228974-01Flindersine

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