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Docarpamine

CAT: 0804-HY-W752502-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-W752502-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Docarpamine is an orally active dopamine prodrug that can be hydroxylated in the small intestine and liver to form active dopamine. Docarpamine mainly activates D1-like receptors in peripheral blood vessels to lower blood pressure and heart rate in a state of spontaneous hypertension. Docarpamine exerts a pressor and tachycardic effect by activating D1-like receptors, vasopressin V1 receptors, and α-adrenergic receptors in normal blood pressure conditions. Docarpamine can be used for research on renal vascular dilation and diuresis[1][2].
CAS Number
74639-40-0
UNSPSC
12352005
Target
Adrenergic Receptor; Dopamine Receptor; Vasopressin Receptor
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Smiles
CCOC(OC1=C(C=C(C=C1)CCNC([C@@H](NC(C)=O)CCSC)=O)OC(OCC)=O)=O
Molecular Formula
C21H30N2O8S
Molecular Weight
470.54
References & Citations
[1]Sanada H, et al. The effect of docarpamine, a dopamine pro-drug, on blood pressure and catecholamine levels in spontaneously hypertensive rats. Clin Exp Hypertens. 2000 May;22 (4) :419-29.|[2]Tsunoda T, et al. Treatment for ovarian hyperstimulation syndrome using an oral dopamine prodrug, docarpamine. Gynecol Endocrinol. 2003 Aug;17 (4) :281-6.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
D1 Receptor; α adrenergic receptor

Alternative Products

CatalogName
AR-D07361-01Docarpamine
AR-D07362-01Rac-Docarpamine
AR-D07360-01Ent-Docarpamine
AR-D07359-01N1-Nitroso Docarpamine
AR-D07358-01N1-Nitroso rac-Docarpamine

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