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Betulinic acid-d3

CAT: 0804-HY-W744739Size: 2.5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-W744739Size:2.5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Betulinic acid-d3 (Lupatic acid-d3) is a deuterium labeled Betulinic acid. Betulinic acid is a natural pentacyclic triterpenoid, acts as a eukaryotic topoisomerase I inhibitor, with an IC50 of 5 μM, and possesses anti-HIV, anti-malarial, anti-inflammatory and anti-tumor properties[1][2][3][4].
Product Name Alternative
Lupatic acid-d3; Betulic acid-d3
UNSPSC
12352211
Target
Apoptosis; Autophagy; Endogenous Metabolite; HIV; Isotope-Labeled Compounds; Mitophagy; NF-κB; Parasite; Topoisomerase
Related Pathways
Anti-infection; Apoptosis; Autophagy; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; NF-κB; Others
Field of Research
Cancer; Infection; Inflammation/Immunology
Smiles
[H][C@]12[C@](C)([C@@]3(CC[C@]4(C(C)([C@]([2H])(C([2H])(C[C@@]4([C@]3(CC2)[H])C)[2H])O)C)[H])C)CC[C@@]5([C@@]1([C@@H](CC5)C(C)=C)[H])C(O)=O
Molecular Formula
C30H45D3O3
Molecular Weight
459.72
References & Citations
[1]Chowdhury AR, et al. Betulinic acid, a potent inhibitor of eukaryotic topoisomerase I: identification of the inhibitory step, the major functional group responsible and development of more potent derivatives. Med Sci Monit. 2002 Jul;8 (7) :BR254-65. |[2]Gao Y, et al. Betulinic acid induces apoptosis and ultrastructural changes in MDA-MB-231 breast cancer cells. Ultrastruct Pathol. 2018 Jan-Feb;42 (1) :49-54. |[3]Kalra J, et al. Betulinic acid alleviates dextran sulfate sodium-induced colitis and visceral pain in mice. Naunyn Schmiedebergs Arch Pharmacol. 2017 Dec 26. |[4]Hashimoto F, et al. Anti-AIDS agents--XXVII. Synthesis and anti-HIV activity of betulinic acid and dihydrobetulinic acid derivatives. Bioorg Med Chem. 1997 Dec;5 (12) :2133-43.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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