Abemaciclib-d5

CAT: 0804-HY-W728130-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-W728130-01Size:1 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Abemaciclib-d5 (LY2835219-d5) is a deuterium labeled Abemaciclib (HY-16297A) [1][2][3].
CAS Number
[1809251-51-1]
Product Name Alternative
LY2835219-d5
UNSPSC
12352005
Target
Isotope-Labeled Compounds
Related Pathways
Others
Field of Research
Cancer
Smiles
CC(N1C(C)C)=NC(C1=CC(C2=C(C=NC(NC3=CC=C(CN4CCN(C([2H])(C([2H])([2H])[2H])[2H])CC4)C=N3)=N2)F)=C5)=C5F
Molecular Formula
C27H27D5F2N8
Molecular Weight
511.62
References & Citations
[1]Ku BM, et al. The CDK4/6 inhibitor LY2835219 has potent activity in combination with mTOR inhibitor in head and neck squamous cell carcinoma. Oncotarget. 2016 Mar 22;7 (12) :14803-13.|[2]Yadav V, et al. The CDK4/6 inhibitor LY2835219 overcomes vemurafenib resistance resulting from MAPK reactivation and cyclin D1 upregulation. Mol Cancer Ther. 2014 Oct;13 (10) :2253-63.|[3]Gelbert LM, et al. Preclinical characterization of the CDK4/6 inhibitor LY2835219: in-vivo cell cycle-dependent/independent anti-tumor activities alone/in combination with gemcitabine. Invest New Drugs. 2014 Oct;32 (5) :825-37.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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TRC-A115154-50MGAbemaciclib-D5
TRC-D115462-100MGDesfluoro-Abemaciclib-D5
RM-A305000-01Abemaciclib
MBS385078-01LY2835219 (abemaciclib)
T3111-01Abemaciclib methanesulfonate
TRC-A115456-25MGAbemaciclib-D8
TRC-D115460-25MGDesfluoro-Abemaciclib
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